Center for Human Nutrition, University of California, Los Angeles, Los Angeles, CA 90095, USA.
J Altern Complement Med. 2010 May;16(5):585-90. doi: 10.1089/acm.2009.0226.
The objective of this study was to examine the effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy elderly subjects.
Twenty (20) healthy elderly (age 50-75 years) subjects were enrolled in this double-blind, placebo-controlled, prospective trial. The subjects were taking either Cs-4 333 mg or placebo capsules 3 times a day for 12 weeks.
Subjects received baseline screening including physical examination and laboratory tests. Maximal incremental exercise testing was performed on a stationary cycle ergometer using breath-by-breath analysis at baseline and at the completion of the study.
After receiving Cs-4 for 12 weeks, the metabolic threshold (above which lactate accumulates) increased by 10.5% from 0.83 +/- 0.06 to 0.93 +/- 0.08 L/min (p < 0.02) and the ventilatory threshold (above which unbuffered H(+) stimulates ventilation) increased by 8.5% from 1.25 +/- 0.11 to 1.36 +/- 0.15 L/min. Significant changes in metabolic or ventilatory threshold were not seen for the subjects in the placebo group after 12 weeks, and there were no changes in Vo(2) max in either group.
This pilot study suggests that supplementation with Cs-4 (Cordyceps sinensis) improves exercise performance and might contribute to wellness in healthy older subjects.
本研究旨在探讨蛹虫草（Cs-4）对健康老年受试者运动表现的影响。
20 名健康老年（50-75 岁）受试者参与了这项双盲、安慰剂对照、前瞻性试验。受试者每天服用蛹虫草 333 毫克或安慰剂胶囊 3 次，共 12 周。
受试者接受了基线筛查，包括体格检查和实验室检查。在基线和研究结束时，使用呼吸分析在固定自行车测力计上进行最大增量运动测试。
接受蛹虫草治疗 12 周后，代谢阈值（乳酸开始积累的水平）从 0.83 +/- 0.06 增加到 0.93 +/- 0.08 L/min，增加了 10.5%（p < 0.02），通气阈值（缓冲 H+ 刺激通气的水平）从 1.25 +/- 0.11 增加到 1.36 +/- 0.15 L/min，增加了 8.5%。在安慰剂组中，12 周后代谢或通气阈值没有显著变化，两组的最大摄氧量也没有变化。
这项初步研究表明，蛹虫草（Cs-4）的补充可以改善运动表现，并可能有助于健康老年受试者的健康。
