Division of Epidemiology, Departments of Urology and Health Sciences Research and Cardiology, Mayo Clinic College of Medicine, Rochester, MN, USA.
BJU Int. 2011 Feb;107(3):443-50. doi: 10.1111/j.1464-410X.2010.09598.x. Epub 2010 Aug 26.
To determine whether statin use is associated with a decreased risk of developing benign prostatic enlargement (BPE) and lower urinary tract symptoms (LUTS).
We conducted a retrospective, population-based cohort study of 2447 men, 40-79 years of age, residing in Olmsted County, MN, USA, in 1990, and followed these men biennially through 2007. Cox proportional hazard models were used to assess associations between statin use and new onset of moderate/severe LUTS (American Urological Association Symptom Index score >7), a decreased maximum urinary flow rate (<12 mL/s) or BPE (prostate volume >30 mL).
Statin use was inversely associated with new onset of LUTS (Hazard ratio (HR) 0.39; 95% confidence interval (CI) 0.31-0.49), a decreased maximum flow rate (HR 0.53; 95% CI 0.34-0.82) and BPE (HR 0.40; 95% CI 0.23-0.69) after adjustment for baseline age and body mass index, diabetes, hypertension, coronary heart disease, smoking, alcohol use, activity level and non-steroidal anti-inflammatory use. The longest duration of statin use was associated with the lowest risk of developing each outcome (all tests for trend: P < 0.001).
In this study, statin use was associated with a 6.5- to 7-year delay in the new onset of moderate/severe LUTS or BPE. While men typically take statin medications to prevent coronary heart disease events and related outcomes, these data suggest that men who use statins may also receive urologic benefits.
确定他汀类药物的使用是否与良性前列腺增生（BPE）和下尿路症状（LUTS）的发生风险降低相关。
我们对美国明尼苏达州奥姆斯特德县 1990 年的 2447 名 40-79 岁男性进行了一项回顾性、基于人群的队列研究，并在 2007 年之前对这些男性进行了每两年一次的随访。使用 Cox 比例风险模型评估了他汀类药物使用与新发生中度/重度 LUTS（美国泌尿外科学会症状指数评分>7）、最大尿流率降低（<12ml/s）或 BPE（前列腺体积>30ml）之间的关联。
在调整基线年龄和体重指数、糖尿病、高血压、冠心病、吸烟、饮酒、活动水平和非甾体抗炎药使用后，他汀类药物的使用与 LUTS 的新发（风险比（HR）0.39；95%置信区间（CI）0.31-0.49）、最大尿流率降低（HR 0.53；95% CI 0.34-0.82）和 BPE（HR 0.40；95% CI 0.23-0.69）呈负相关。他汀类药物使用的最长持续时间与每种结局的最低风险相关（所有趋势检验：P<0.001）。
在这项研究中，他汀类药物的使用与新发中度/重度 LUTS 或 BPE 的发生时间延迟了 6.5-7 年。虽然男性通常使用他汀类药物来预防冠心病事件及其相关结局，但这些数据表明，使用他汀类药物的男性可能还会获得泌尿科方面的益处。
