Parsons J Kellogg, Bergstrom Jaclyn, Barrett-Connor Elizabeth
Division of Urology, Department of Surgery, University of California San Diego School of Medicine, La Jolla, CA 21287, USA.
BJU Int. 2008 Feb;101(3):313-8. doi: 10.1111/j.1464-410X.2007.07332.x. Epub 2007 Nov 13.
To examine the associations of serum lipids and lipoproteins with benign prostatic hyperplasia (BPH) in community-dwelling men.
This analysis was conducted within the Rancho Bernardo Study, a prospective, community-based cohort study. BPH was defined as a history of prostate surgery for other than cancer, or a medical diagnosis of BPH. Logistic regression modelling, with adjustments for age and stratification by diabetes diagnosis, was used to estimate the odds ratio (OR) of BPH associated with fasting serum concentrations of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, and the triglyceride to HDL ratio.
Among 531 eligible participants, 259 (48%) reported BPH and 272 (52%) reported no BPH. Men with BPH, with a mean (range) age of 75.8 (76.1-80.1) years, were older than men without BPH , at 72.7 (72.4-74.0) years. There were no significant associations of total cholesterol (P trend, 0.52), HDL cholesterol (0.56), triglycerides (0.30), or triglyceride to HDL ratio (0.13) with the risk of BPH. In a subset analysis in men with diabetes, those in the highest tertile (>133 mg/dL) of LDL cholesterol, compared with those in the lowest tertile (<110 mg/dL), were four times more likely to have BPH (odds ratio 4.00, 95% confidence interval 1.27-12.63, P trend 0.02). These results were not explained by the use of statins.
In these community-dwelling men, higher serum LDL was associated with a greater risk of BPH among diabetics. These data suggest that diabetic men with increased LDL cholesterol are at greater risk of BPH. This observation is consistent with the concept that cardiac risk factors are involved with the pathogenesis of BPH.
研究社区男性居民血清脂质和脂蛋白与良性前列腺增生（BPH）之间的关联。
本分析在兰乔贝纳多研究中进行，这是一项基于社区的前瞻性队列研究。BPH定义为非癌症原因的前列腺手术史或BPH的医学诊断。采用逻辑回归模型，并对年龄进行调整，按糖尿病诊断分层，以估计空腹血清总胆固醇、高密度脂蛋白（HDL）胆固醇、低密度脂蛋白（LDL）胆固醇、甘油三酯以及甘油三酯与HDL比值与BPH相关的比值比（OR）。
在531名符合条件的参与者中，259人（48%）报告患有BPH，272人（52%）报告未患BPH。患有BPH的男性平均（范围）年龄为75.8（76.1 - 80.1）岁，比未患BPH的男性年龄大，后者为72.7（72.4 - 74.0）岁。总胆固醇（P趋势，0.52）、HDL胆固醇（0.56）、甘油三酯（0.30）或甘油三酯与HDL比值（0.13）与BPH风险之间无显著关联。在糖尿病男性的亚组分析中，LDL胆固醇处于最高三分位数（>133 mg/dL）的男性与处于最低三分位数（<110 mg/dL）的男性相比，患BPH的可能性高四倍（比值比4.00，95%置信区间1.27 - 12.63，P趋势0.02）。这些结果无法用他汀类药物的使用来解释。
在这些社区男性居民中，较高的血清LDL与糖尿病患者患BPH的风险增加相关。这些数据表明，LDL胆固醇升高的糖尿病男性患BPH的风险更大。这一观察结果与心脏危险因素参与BPH发病机制的概念一致。
