Talsania Narmita, Harwood Catherine A, Piras D, Cerio Rino
Barts and The London NHS Trust, London, UK.
Dermatol Online J. 2010 Aug 15;16(8):8.
Paraneoplastic acanthosis nigricans (P-AN) characteristically has a sudden onset, rapid progression, and extensive cutaneous involvement. The association between P-AN and internal malignancy is well established and the most common association is with adenocarcinoma of gastrointestinal origin. We present the case of an 81-year-old man with a 12-month history of anorexia, weight loss, and clinical evidence of extensive acanthosis nigricans. After exhaustive and repeated investigations a papillary thyroid carcinoma and a follicular adenoma were identified and he improved upon its resection. To our knowledge, P-AN in association with thyroid neoplasm has been reported on only one previous occasion.
副肿瘤性黑棘皮病（P-AN）的特征是起病突然、进展迅速且皮肤广泛受累。P-AN与体内恶性肿瘤之间的关联已得到充分证实，最常见的关联是与胃肠道起源的腺癌。我们报告一例81岁男性病例，该患者有12个月的厌食、体重减轻病史，并有广泛黑棘皮病的临床证据。经过详尽且反复的检查，确诊为乳头状甲状腺癌和滤泡性腺瘤，切除肿瘤后患者病情有所改善。据我们所知，P-AN与甲状腺肿瘤相关的病例此前仅报道过一例。
