Ranieri Maurizio, Sciuscio Manuela, Cortese Annamaria, Stasi Marilena, Panza Francesco, Megna Marisa, Fiore Pietro, Santamato Andrea
Department of Physical Medicine and Rehabilitation, University of Foggia, Foggia, Italy.
J Brachial Plex Peripher Nerve Inj. 2010 Aug 31;5:15. doi: 10.1186/1749-7221-5-15.
Recent findings on the antioxidant effects of pretreatment with α-lipoic acid (α-LA) on the crush injury of rat sciatic nerve confirm the possible usefulness of α-LA administration in humans with peripheral nerve injuries. We discussed this issue in relation with our recent results in which the combined employment of α-LA and γ-linolenic acid with a rehabilitation program for six weeks reduced sensory symptoms and neuropathic pain in patients with compressive radiculopathy syndrome from disc-nerve root conflict in comparison with patients submitted to rehabilitation program alone for six weeks.
近期关于α-硫辛酸（α-LA）预处理对大鼠坐骨神经挤压伤抗氧化作用的研究结果证实，α-LA给药对人类周围神经损伤可能具有一定作用。我们结合近期的研究结果讨论了这一问题，在这些研究中，与仅接受六周康复治疗的患者相比，α-LA和γ-亚麻酸联合康复治疗六周可减轻因椎间盘-神经根冲突导致的压迫性神经根病综合征患者的感觉症状和神经性疼痛。
