Francis Edwin, Gayathri S, Vaidyanathan Balu, Kannan B R J, Kumar R Krishna
Department of Pediatric Cardiology, Amrita Institute of Medical Sciences and Research Center, Kochi, India.
Ann Pediatr Cardiol. 2009 Jul;2(2):111-5. doi: 10.4103/0974-2069.58311.
Management of native uncomplicated coarctation in neonates remains controversial with current evidence favoring surgery. The logistics of organizing surgical repair at short notice in sick infants with critical coarctation can be challenging.
We reviewed data of 10 infants (mean age of 2.9 +/-1.6 weeks) who underwent catheter intervention for severe coarctation and left ventricular (LV) dysfunction between July 2003 and August 2007. Additional cardiac lesions were present in 7. Mean systolic gradient declined from 51+/-12 mm Hg to 8.7+/-6.7 mm Hg after dilation. The coarctation segment was stented in five patients. Procedural success was achieved in all patients with no mortality. Complications included brief cardiopulmonary arrest (n =1), sepsis (n = 1) and temporary pulse loss (n = 2). LV dysfunction improved in all patients. Average ICU stay was 5+/-3.4 days and hospital stay was 6.5+/-3.4 days. On follow-up (14.1+/-10.5 months), all developed restenosis after median period of 12 weeks (range four to 28 weeks). Three (two with stents) underwent elective coarctation repair, two underwent ventricular septal defect (VSD) closure and coarctation repair and one underwent pulmonary artery (PA) banding. Two patients who developed restenosis on follow-up were advised surgery, but did not report. Two (one with stent) underwent redilatation and are being followed with no significant residual gradients.
Balloon dilation +/- stenting is an effective interim palliation for infants and newborns with critical coarctation and LV dysfunction. Restenosis is inevitable and requires to be addressed.
对于新生儿单纯性主动脉缩窄的治疗目前仍存在争议,现有证据支持手术治疗。对于病情危急的主动脉缩窄病婴,在短时间内安排手术修复的后勤保障工作颇具挑战性。
我们回顾了2003年7月至2007年8月期间10例(平均年龄2.9±1.6周)因严重主动脉缩窄和左心室功能障碍接受导管介入治疗的婴儿的数据。7例存在其他心脏病变。扩张后平均收缩期压差从51±12 mmHg降至8.7±6.7 mmHg。5例患者的缩窄段置入了支架。所有患者均获得手术成功,无死亡病例。并发症包括短暂心肺骤停(1例)、败血症(1例)和暂时性脉搏消失(2例)。所有患者的左心室功能障碍均有改善。平均重症监护病房住院时间为5±3.4天,住院时间为6.5±3.4天。随访(14.1±10.5个月)时,所有患者在中位时间12周(4至28周)后均出现再狭窄。3例(2例置入支架)接受了择期主动脉缩窄修复术,2例接受了室间隔缺损封堵和主动脉缩窄修复术,1例接受了肺动脉环扎术。2例随访时出现再狭窄的患者被告知手术,但未进行手术。2例(1例置入支架)接受了再次扩张,目前正在随访,无明显残余压差。
球囊扩张±支架置入术是治疗病情危急的主动脉缩窄和左心室功能障碍婴儿及新生儿的有效临时姑息治疗方法。再狭窄不可避免,需要加以处理。