Galárraga Iván Marcelo Cueva
Plastic Surgery Service, Club de Leones Quito Central, Central Médico Comunitario, Quito, Pichincha, Ecuador.
Can J Plast Surg. 2009 Fall;17(3):e1-2. doi: 10.1177/229255030901700313.
To determine if the use of botulinum toxin during cheiloplasty could help in the management of tension at the surgical wound level.
Five children younger than six months of age, who were born with complete cleft lip and palate, were treated with a dose of 10 units of botulinum toxin injected into the upper lip during surgery. Before the surgery, an electromyographic study was carried out on the patients' upper lips. A Millard-type cheiloplasty was performed and 10 days later, a second electromyographic study was performed on the upper lips of all the patients.
There was a significant change (P<0.039) in the electromyographic tracing obtained after the application of botulinum toxin, especially during rest.
As confirmed by electromyography, botulinum toxin effectively inhibits the action of the orbicularis oris muscle, especially when at rest; consequently, the tension is decreased at the level of the surgical wound.
确定在唇裂修复术中使用肉毒杆菌毒素是否有助于处理手术伤口处的张力。
五名年龄小于六个月、患有完全性唇腭裂的儿童在手术期间接受了在上唇注射10单位肉毒杆菌毒素的治疗。手术前，对患者的上唇进行了肌电图研究。实施了Millard式唇裂修复术，10天后，对所有患者的上唇进行了第二次肌电图研究。
应用肉毒杆菌毒素后获得的肌电图描记有显著变化（P<0.039），尤其是在静止状态下。
经肌电图证实，肉毒杆菌毒素能有效抑制口轮匝肌的作用，尤其是在静止时；因此，手术伤口处的张力降低。
