Laboratoire AMAPP, EA 4248, UFR STAPS, Université d'Orléans, Allée du Château, BP 6237, 45062 Orléans Cedex 2, France.
J Physiol Sci. 2010 Nov;60(6):435-9. doi: 10.1007/s12576-010-0106-y. Epub 2010 Aug 31.
This study examined the relationships between plasma and saliva adrenocortical hormones in response to long-duration submaximal exercise. In nine healthy, physically active, female volunteers, blood and saliva samples were taken at rest and every 30 min during a 120-min cycling trial at 50-55% VO(2max) for cortisol and dehydroepiandrosterone (DHEA) analysis. Correlation analysis revealed a moderate but significant relationship between plasma and saliva cortisol (r = 0.35, P < 0.02) and plasma and saliva DHEA (r = 0.47, P < 0.001) during the submaximal exercise. When expressed in percent of resting values, the correlations between the plasma and saliva concentrations were higher for both hormones during the exercise (cortisol: r = 0.72; DHEA: r = 0.68, P < 0.001). The results thus suggest that, even under prolonged exercise conditions, non-invasive saliva samples may offer a practical approach to assessing pituitary-adrenal function, especially when compared with individual basal values.
本研究旨在探讨长期亚极量运动时，血浆和唾液肾上腺皮质激素之间的关系。在 9 名健康、有运动习惯的女性志愿者中，在 50-55% VO(2max)的 120 分钟踏车运动中，每 30 分钟采集一次血样和唾液样，用于皮质醇和脱氢表雄酮（DHEA）分析。相关分析显示，在亚极量运动时，血浆和唾液皮质醇之间存在中等强度但显著的关系（r = 0.35，P < 0.02），血浆和唾液 DHEA 之间也存在中等强度但显著的关系（r = 0.47，P < 0.001）。当以静息值的百分比表示时，两种激素在运动期间，血浆和唾液浓度之间的相关性更高（皮质醇：r = 0.72；DHEA：r = 0.68，P < 0.001）。因此，这些结果表明，即使在长时间运动的情况下，非侵入性的唾液样本也可能提供一种评估垂体-肾上腺功能的实用方法，尤其是与个体基础值相比时。
