Division of Thoracic Oncology, Shizuoka Cancer Center, Sunto-gun, Shizuoka 411-8777, Japan.
Oncol Rep. 2010 Oct;24(4):861-7. doi: 10.3892/or.2010.861.
CD98 has been associated with tumor growth and is highly expressed in human neoplasms. The aim of this study was to evaluate the clinicopathological significance of CD98 expression in thymic epithelial tumors. Forty-nine patients with thymic epithelial tumors were included in this study. Tumor sections were stained by immunohistochemistry for CD98; vascular endothelial growth factor (VEGF); micro-vessels (CD31 and CD34); cell cycle control marker (p53); and apoptosis marker (Bcl-2). CD98 expression for low-risk thymomas, high-risk thymomas, and thymic carcinomas were 1 (4%) of 27, 9 (82%) of 11, and 11 (100%) of 11, respectively. There was positive correlation between CD98 and VEGF (p<0.001), microvessel density (CD31 and CD34) (p<0.001) and p53 (p<0.001). However, Bcl-2 showed no positive correlation with CD98 expression. The expression of CD98 were also significantly associated with the grade of malignancy in thymic epithelial tumors. Multivariate analysis revealed that overexpression of CD98 was a significant independent factor predicting a poor outcome in thymic epithelial tumors. CD98 expression was associated with the grade of malignancy in thymic epithelial tumors. Moreover, CD98 expression was closely correlated with angiogenesis and cell cycle control, and was useful for predicting poor outcome.
CD98 与肿瘤生长有关，在人类肿瘤中高度表达。本研究旨在评估 CD98 表达在胸腺瘤中的临床病理意义。本研究纳入 49 例胸腺瘤患者。肿瘤切片通过免疫组织化学方法对 CD98、血管内皮生长因子（VEGF）、微血管（CD31 和 CD34）、细胞周期控制标志物（p53）和凋亡标志物（Bcl-2）进行染色。低危胸腺瘤、高危胸腺瘤和胸腺癌的 CD98 表达分别为 27 例中的 1 例（4%）、11 例中的 9 例（82%）和 11 例中的 11 例（100%）。CD98 与 VEGF（p<0.001）、微血管密度（CD31 和 CD34）（p<0.001）和 p53（p<0.001）之间存在正相关。然而，Bcl-2 与 CD98 表达无正相关。CD98 的表达也与胸腺瘤的恶性程度显著相关。多变量分析显示，CD98 过表达是胸腺瘤不良预后的显著独立因素。CD98 表达与胸腺瘤的恶性程度相关。此外，CD98 表达与血管生成和细胞周期控制密切相关，有助于预测不良预后。
