一种用于 NMR 接收机增益压缩的快速诊断测试方法。
A quick diagnostic test for NMR receiver gain compression.
机构信息
Purdue Interdepartmental NMR Facility, Purdue University, West Lafayette, IN 47907, USA.
出版信息
Magn Reson Chem. 2010 Oct;48(10):782-6. doi: 10.1002/mrc.2662.
Modern NMR spectrometers require receivers to work within their linear ranges to maintain high fidelity line shape and peak integration. For better sensitivity, the receiver gain has to be optimized to detect dilute analytes; however, gain compression needs to be avoided. Here, we explore if and how linear receiver performance can be achieved for a couple of representative gain settings on a spectrometer. In the case of slight receiver gain compression, not only will the peak integral be attenuated but a very small line-shape change can also be observed. Hence, we can resort to resonance integration and line-shape analysis for gain compression diagnosis. As such, NMR signals, regardless of their observed amplitude difference in frequency domain, can be accurately compared in quantitative analysis.
现代 NMR 光谱仪要求接收器在其线性范围内工作，以保持高保真度的线形和峰积分。为了提高灵敏度，必须优化接收器增益以检测稀有的分析物；然而，需要避免增益压缩。在这里，我们探讨了在光谱仪上的几个代表性增益设置下是否以及如何实现线性接收器性能。在接收器增益轻微压缩的情况下，不仅峰积分会衰减，而且还可以观察到非常小的线形变化。因此，我们可以采用共振积分和线形分析来进行增益压缩诊断。这样，无论 NMR 信号在频域中观察到的幅度差异如何，都可以在定量分析中进行准确比较。
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