环戊二烯基配体的镧系（III）螯合物中 SAP 和 TSAP 异构体的比例受溶剂的影响很大。
The population of SAP and TSAP isomers in cyclen-based lanthanide(III) chelates is substantially affected by solvent.
机构信息
Department of Chemistry, University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 7080, USA.
出版信息
Inorg Chem. 2010 Oct 4;49(19):8662-4. doi: 10.1021/ic101489t.
Abstract
The square antiprism/twisted square antiprism ratio in LnDOTA-tetraamide chelates is a critical parameter in governing water-exchange kinetics and ultimately the utility of a chelate as a PARACEST MRI contrast agent. In LnDOTA-tetraamide chelates with tertiary amides, this ratio and the rate of interconversion between these two structural isomers are found to be dramatically dependent upon the solvent and possibly other local environmental factors.
摘要
LnDOTA-四酰胺螯合物中正方形反棱柱/扭曲正方形反棱柱的比例是控制水交换动力学的关键参数，最终决定了螯合物作为 PARACEST MRI 对比剂的用途。在具有叔酰胺的 LnDOTA-四酰胺螯合物中，该比例以及这两种结构异构体之间的互变异构体的速率被发现极大地依赖于溶剂和可能的其他局部环境因素。
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