指甲中的微量元素作为临床研究的生物标志物。
Trace elements in nails as biomarkers in clinical research.
机构信息
Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7461, USA.
出版信息
Eur J Clin Invest. 2011 Jan;41(1):98-102. doi: 10.1111/j.1365-2362.2010.02373.x. Epub 2010 Aug 31.
Abstract
BACKGROUND
The importance of trace elements in relation to human health has been increasingly recognized. Accurate and adequate quantification of trace elements are crucial in clinical research.
DESIGN
This review was to discuss the rationale of using nail trace elements as biomarkers in clinical studies.
RESULTS
For most trace elements, dietary instruments cannot appropriately capture the intakes because of the minimal amounts and wide variations in the same foods grown in different area as well as the nondietary exposures. Therefore, biomarkers may be essential in studying trace elements. Although there are notable differences among trace elements in the availability of biomarkers, increasing evidence supports that nails, particularly toenail concentrations of most trace elements, are useful biomarkers of exposure in which a single sample is assumed to represent long-term exposure.
CONCLUSIONS
Compared with other potential biomarkers of trace elements, nail measurement has certain advantages in clinical research.
摘要
背景
微量元素与人类健康的关系的重要性已逐渐被认识到。准确和充分的微量元素定量在临床研究中至关重要。
设计
本综述旨在讨论将指甲微量元素作为临床研究中生物标志物的基本原理。
结果
对于大多数微量元素，由于同一食物在不同地区的微量和广泛差异以及非饮食暴露，膳食仪器不能适当捕捉摄入量。因此，生物标志物在研究微量元素时可能是必不可少的。尽管生物标志物的可用性存在明显差异，但越来越多的证据支持指甲，特别是大多数微量元素的趾甲浓度，是暴露的有用生物标志物，其中一个样本被认为代表长期暴露。
结论
与其他潜在的微量元素生物标志物相比，指甲测量在临床研究中有一定的优势。
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