Gold P E, Sternberg D B
Science. 1978 Jul 28;201(4353):367-9. doi: 10.1126/science.208153.
This experiment examined the effects on memory of various amnestic treatments in animals earlier treated with the alpha-adrenergic antagonist phenoxybenzamine (PBZ). Thirty minutes before being trained in a one-trial inhibitory (passive) avoidance task, animals received an injection of PBZ or saline. Immediately after training, each animal received one of the following amnestic treatments: stimulation of the frontal cortex or amygdala, pentylenetetrazol, diethyldithiocarbamate, or cycloheximide. In control animals, each treatment produced retrograde amnesia. However, PBZ-treated animals did not develop amnesia. These findings suggest that there may be a common neurobiological mechanism underlying the amnesias produced by many treatments.
本实验研究了在早期用α-肾上腺素能拮抗剂苯氧苄胺（PBZ）处理过的动物中，各种遗忘处理对记忆的影响。在进行单次抑制性（被动）回避任务训练前30分钟，给动物注射PBZ或生理盐水。训练后立即给每只动物进行以下遗忘处理之一：刺激额叶皮层或杏仁核、戊四氮、二乙基二硫代氨基甲酸盐或环己酰亚胺。在对照动物中，每种处理都产生了逆行性遗忘。然而，用PBZ处理过的动物并未出现遗忘。这些发现表明，许多处理所产生的遗忘可能存在共同的神经生物学机制。
