Skakun N P, Klimniuk E V
Farmakol Toksikol. 1990 Nov-Dec;53(6):52-4.
In experiments on albino rats it was established that three administrations of indomethacin in a dose of 0.01 g/kg body weight induced a severe damage of the liver characterized by disturbances of hepatocytic membranes, bile-producing and protein-producing functions of the liver, an enhancement of lipid peroxidation, a decrease of reduced glutathione pool. Antioxidants (tocopherol acetate, essentiale, legalon, flacumin) limit manifestations of indomethacin, hepatotoxicity, as a result of which tha functional-biochemical disorders in the liver show up to a lesser degree. During the combined use of antioxidants in indomethacin-induced lesions of the liver their hepatoprotective activity increases.
在对白化病大鼠的实验中发现，以0.01 g/kg体重的剂量三次给予吲哚美辛会导致肝脏严重损伤，其特征为肝细胞膜紊乱、肝脏胆汁生成和蛋白质生成功能障碍、脂质过氧化增强、还原型谷胱甘肽池减少。抗氧化剂（醋酸生育酚、易善复、利加隆、福拉明）可限制吲哚美辛的肝毒性表现，结果肝脏中的功能生化紊乱程度较轻。在吲哚美辛诱导的肝脏损伤中联合使用抗氧化剂时，它们的肝保护活性会增强。
