Klimniuk E V
Farmakol Toksikol. 1989 Mar-Apr;52(2):81-2.
Administration of indomethacin in a dose of 0.01 and especially in a dose of 0.02 mg/kg body weight three times was found to cause a severe damage of the liver. It manifested itself in an increase of the activity of aminotransferases and alkaline phosphatase in blood serum, an increase of peroxidation of lipids of hepatocytic membranes, a decrease of reserves of restored glutathione, a disturbance of the functional state of the liver. The increase of lipid peroxidation is thought to play an important role in the pathogenesis of such lesions.
发现以0.01毫克/千克体重的剂量，尤其是以0.02毫克/千克体重的剂量三次给予吲哚美辛会导致肝脏严重损伤。其表现为血清中氨基转移酶和碱性磷酸酶活性增加、肝细胞膜脂质过氧化增加、还原型谷胱甘肽储备减少、肝脏功能状态紊乱。脂质过氧化增加被认为在这类病变的发病机制中起重要作用。
