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[乙醇对大鼠血清蛋白的急性和慢性作用]

[The acute and chronic action of ethanol on blood serum proteins in rats].

作者信息

Bozhko G Kh, Strelianaia E I, Voloshin P V

出版信息

Farmakol Toksikol. 1990 Nov-Dec;53(6):56.

PMID:2081571
Abstract

The results of electrophoresis of blood serum proteins (BSP) in rats evidence that degradation of lipoproteins and one polypeptide of the postalbumin zone was observed after a single administration of ethanol in a dose of 4 g/kg. A daily administration of ethanol for one month was attended by a quantitative redistribution of BSP fractions due to their aggregation. The comparison of the effects of ethanol and acetaldehyde suggests that the change in BSP spectra observed under long-term alcoholization is produced by acetaldehyde action and is connected with the formation of polypeptide complexes. At a single and long-term use of ethanol there were no changes in the concentrations of common BSP.

摘要

大鼠血清蛋白(BSP)电泳结果表明,单次给予4 g/kg剂量的乙醇后,观察到脂蛋白和后白蛋白区的一种多肽发生降解。连续一个月每日给予乙醇会导致BSP各组分因聚集而发生定量重新分布。乙醇和乙醛作用效果的比较表明,长期酒精化条件下观察到的BSP谱变化是由乙醛作用产生的,并且与多肽复合物的形成有关。单次和长期使用乙醇时,常见BSP的浓度均无变化。

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