Elmér O, Göransson G, Saku M, Bengmark S
Thromb Haemost. 1977 Apr 30;37(2):344-50.
Increased microaggregate formation was found after mixing ethanol with blood from pig and rabbit in vitro, measured with Swank's Screen Filtration pressure method. Final ethanol concentrations were in the range found in ethanol-intoxication in man. No rise in SFP was noticed when plasma with 10,000 platelets/microliter was used. It is therefore doubtful that altered plasma proteins caused the rise in SFP. It is suggested that if a direct effect of ethanol upon platelet aggregation exists in vivo, it may be of importance in acute ethanol intoxication and in chronic alcoholism.
体外将乙醇与猪和兔的血液混合后,采用斯旺克滤网过滤压力法测量发现微聚集体形成增加。最终乙醇浓度处于人体乙醇中毒时的浓度范围内。当使用每微升含10000个血小板的血浆时,未观察到滤网过滤压力(SFP)升高。因此,血浆蛋白改变导致SFP升高这一点值得怀疑。有人提出,如果乙醇在体内对血小板聚集有直接作用,那么它可能在急性乙醇中毒和慢性酒精中毒中起重要作用。