Department of Psychology, Northern Illinois University, DeKalb, IL 60115, USA.
Behav Brain Res. 2011 Jan 20;216(2):726-30. doi: 10.1016/j.bbr.2010.08.041. Epub 2010 Sep 9.
The present experiment assessed whether preadolescent exposure to methamphetamine would alter adult behavioral responses to cocaine and dopamine transporter immunoreactivity in the striatum of male and female rats. Juvenile rats were injected once daily with 0 or 2 mg/kg methamphetamine from postnatal days 21 to 35 and tested in adulthood. Male rats, but not female rats, exposed to methamphetamine showed an increase in responsiveness to cocaine in the open field and an increase in dopamine transporter immunoreactivity in the striatum. These findings suggest that early exposure to methamphetamine can lead to sex specific altered responses to psychostimulants in adulthood, which may contribute to later vulnerability to drug use.
本实验评估了幼年时期接触冰毒是否会改变雄性和雌性大鼠成年后对可卡因和纹状体多巴胺转运蛋白免疫反应的行为反应。幼年大鼠从出生后第 21 天到 35 天每天接受 0 或 2mg/kg 的冰毒注射，并在成年后进行测试。暴露于冰毒的雄性大鼠而非雌性大鼠在开放场中对可卡因的反应性增加，并且纹状体中的多巴胺转运蛋白免疫反应性增加。这些发现表明，早期接触冰毒会导致成年后对精神兴奋剂产生特定的性别反应改变，这可能导致以后对药物使用的易感性增加。
