可卡因依赖者的多巴胺转运体水平
Dopamine transporter levels in cocaine dependent subjects.
作者信息
Crits-Christoph Paul, Newberg Andrew, Wintering Nancy, Ploessl Karl, Gibbons Mary Beth Connolly, Ring-Kurtz Sarah, Gallop Robert, Present Julie
机构信息
Department of Psychiatry, University of Pennsylvania, 3535 Market Street, Suite 650, Philadelphia, PA 19104, USA.
出版信息
Drug Alcohol Depend. 2008 Nov 1;98(1-2):70-6. doi: 10.1016/j.drugalcdep.2008.04.014. Epub 2008 Jun 20.
Cocaine use is a significant problem in the US and it is well established that cocaine binds to the dopamine transporter (DAT) in the brain. This study was designed to determine if the DAT levels measured by 99mTc TRODAT SPECT (single photon emission computed tomography) brain scans are altered in cocaine dependent subjects and to explore clinical correlates of such alterations. SPECT brain scans were acquired on 21 cocaine dependent subjects and 21 healthy matched controls. There were significantly higher DAT levels in cocaine dependent subjects compared to controls for the anterior putamen (p=0.003; Cohen's d effect size=0.98), posterior putamen (p<0.001; effect size=1.32), and caudate (p=0.003; effect size=0.97). DAT levels in these regions were 10%, 17%, and 8% higher in the cocaine dependent subjects compared to controls. DAT levels were unrelated to craving, severity of cocaine use, or duration of cocaine use, but DAT levels in the caudate and anterior putamen were significantly (p<0.05) negatively correlated with days since last use of cocaine.
在美国，使用可卡因是一个严重的问题，而且可卡因与大脑中的多巴胺转运体（DAT）结合这一点已得到充分证实。本研究旨在确定通过99mTc TRODAT单光子发射计算机断层扫描（SPECT）脑部扫描测量的DAT水平在可卡因依赖者中是否发生改变，并探讨这种改变的临床相关性。对21名可卡因依赖者和21名健康匹配对照者进行了SPECT脑部扫描。与对照组相比，可卡因依赖者前壳核（p = 0.003；科恩d效应量 = 0.98）、后壳核（p < 0.001；效应量 = 1.32）和尾状核（p = 0.003；效应量 = 0.97）的DAT水平显著更高。与对照组相比，可卡因依赖者这些区域的DAT水平分别高出10%、17%和8%。DAT水平与渴望程度、可卡因使用严重程度或使用持续时间无关，但尾状核和前壳核的DAT水平与上次使用可卡因后的天数显著负相关（p < 0.05）。
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