Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Valdeolmos, Madrid, Spain.
J Immunol Res. 2017;2017:6104054. doi: 10.1155/2017/6104054. Epub 2017 Feb 20.
The anti-inflammatory master regulator IL-10 is critical to protect the host from tissue damage during acute phases of immune responses. This regulatory mechanism, central to T cell homeostasis, can be hijacked by viruses to evade immunity. IL-10 can be produced by virtually all immune cells, and it can also modulate the function of these cells. Understanding the effects of this multifunctional cytokine is therefore a complex task. In the present review we discuss the factors driving IL-10 production and the cellular sources of the cytokine during antiviral immune responses. We particularly focus on the IL-10 regulatory mechanisms that impact antiviral immune responses and how viruses can use this central regulatory pathway to evade immunity and establish chronic/latent infections.
抗炎主调节因子 IL-10 对于保护宿主在免疫反应的急性期免受组织损伤至关重要。这种调节机制是 T 细胞稳态的核心，可以被病毒劫持以逃避免疫。IL-10 几乎可以由所有免疫细胞产生，也可以调节这些细胞的功能。因此，了解这种多功能细胞因子的作用是一项复杂的任务。在本综述中，我们讨论了驱动 IL-10 产生的因素以及抗病毒免疫反应期间细胞因子的细胞来源。我们特别关注影响抗病毒免疫反应的 IL-10 调节机制，以及病毒如何利用这条核心调节途径逃避免疫并建立慢性/潜伏感染。
