Department of Surgery (Neurosurgery), Duke University Medical Center, Durham, NC 27710, USA.
Neurobiol Aging. 2010 Dec;31(12):2181-4. doi: 10.1016/j.neurobiolaging.2010.06.025.
Simple correlations between the overall hippocampal neurogenesis and the hippocampal-dependent learning and memory functions are common in the neurogenesis field. There is considerable evidence in the literature to link hippocampal neurogenesis to the hippocampal-dependent memory function. However, simple correlations between neurogenesis and memory function, particularly in studies where neither the cause-effect relationship is established nor the other relevant variables are considered, can lead to erroneous conclusions. As reliable and selective neurogenesis ablation techniques are yet to be developed for rat and higher animal models, it is likely that correlative studies between the overall neurogenesis and the memory function will continue in different conditions in these animal models. Such correlations should be acceptable as long as the other variables are considered adequately. Furthermore, in correlative analyses of the learning and memory function with the newly born granule cells, one needs to consider the age of the newly born granule cells because the newly born granule cells will require at least a few weeks of time after their birth to participate in the learning and memory function in rodent models.
在神经发生领域，海马体神经发生与海马体依赖的学习和记忆功能之间存在简单的相关性是很常见的。文献中有大量证据表明海马体神经发生与海马体依赖的记忆功能有关。然而，神经发生和记忆功能之间的简单相关性，特别是在没有确定因果关系或没有考虑其他相关变量的研究中，可能会导致错误的结论。由于可靠和选择性的神经发生消融技术尚未在大鼠和高等动物模型中开发出来，因此在这些动物模型的不同条件下，总体神经发生和记忆功能之间的相关性研究可能会继续进行。只要充分考虑其他变量，这种相关性是可以接受的。此外，在将学习和记忆功能与新生颗粒细胞进行相关分析时，需要考虑新生颗粒细胞的年龄，因为在啮齿类动物模型中，新生颗粒细胞需要出生后至少几周的时间才能参与学习和记忆功能。
