Department of Young Leaders' Program in HealthCare Administration, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.
Rheumatology (Oxford). 2010 Dec;49(12):2400-7. doi: 10.1093/rheumatology/keq274. Epub 2010 Sep 3.
To characterize the body composition, to determine the prevalence of metabolic syndrome (MetS), and to examine the association between body composition and the components of MetS in Vietnamese patients with primary gout.
A total of 107 males with gout and 107 age-matched healthy males underwent physical examination, body composition assessment by dual-energy X-ray absorptiometry and blood tests. Both the original and revised National Cholesterol Education Program Adult Treatment Panel (NCEP/ATP) III criteria were used to define MetS.
Means of total body and trunk fat mass in patients with gout were higher (P<0.001) than those in controls: 20.9 vs 13.3 kg and 11.4 vs 6.1 kg, respectively. The prevalence of MetS according to the original and revised NCEP/ATP III criteria in patients with gout was also higher (P<0.001) than in controls (33.6 vs 15.9% and 56.1 vs 23.4%), respectively. In patients with gout, total fat mass was strongly correlated with BMI (r=0.86, P<0.001), while trunk fat mass was strongly correlated with waist circumference (r=0.91, P<0.001). Total fat mass, trunk fat mass and trunk fat mass/legs fat mass ratio were positively correlated (P<0.05) with glycaemia, triglyceridaemia, blood pressure and negatively correlated (P<0.05) with high-density liproprotein cholesterol levels.
Patients with gout had significantly higher fat mass, especially in the trunk region, and higher prevalence of MetS than healthy controls. Therefore, management of weight and MetS should be emphasized in patients with gout to reduce their risk of cardiovascular diseases.
描述人体成分，确定代谢综合征（MetS）的患病率，并研究越南原发性痛风患者的人体成分与 MetS 成分之间的关系。
共纳入 107 名男性痛风患者和 107 名年龄匹配的健康男性，进行体格检查、双能 X 射线吸收法进行人体成分评估和血液检查。采用原始和修订后的国家胆固醇教育计划成人治疗专家组 (NCEP/ATP) III 标准来定义 MetS。
痛风患者的全身和躯干脂肪质量均值高于对照组（P<0.001）：分别为 20.9kg 和 11.4kg 比 13.3kg 和 6.1kg。根据原始和修订后的 NCEP/ATP III 标准，痛风患者的 MetS 患病率也高于对照组（分别为 33.6%比 15.9%和 56.1%比 23.4%）（P<0.001）。在痛风患者中，总脂肪质量与 BMI 呈强相关性（r=0.86，P<0.001），而躯干脂肪质量与腰围呈强相关性（r=0.91，P<0.001）。总脂肪质量、躯干脂肪质量和躯干脂肪质量/腿部脂肪质量比值与血糖、甘油三酯呈正相关（P<0.05），与高密度脂蛋白胆固醇呈负相关（P<0.05）。
痛风患者的脂肪质量明显较高，尤其是躯干脂肪，且 MetS 的患病率高于健康对照组。因此，应强调对痛风患者进行体重和 MetS 的管理，以降低其心血管疾病风险。
