Rho Young Hee, Choi Seong Jae, Lee Young Ho, Ji Jong Dae, Choi Kyung Mook, Baik Sei Hyun, Chung Seung-hie, Kim Chae-Gi, Choe Jung-Yoon, Lee Sung Won, Chung Won Tae, Song Gwan Gyu
Division of Rheumatology, Korea University Anam Hospital, Seoul, Korea.
J Korean Med Sci. 2005 Dec;20(6):1029-33. doi: 10.3346/jkms.2005.20.6.1029.
It has been suggested that hyperuricemia and possibly gout are associated with the metabolic syndrome, but there have been no direct studies. This study was undertaken to obtain the prevalence of the metabolic syndrome in patients with gout and to compare it with those from the general population studies. This was a 4-institutional case-historical control study composed of 168 patients with gout. We assessed the prevalence of metabolic syndrome according to the ATP III criteria and compared the prevalence with that of the historical controls. To elucidate the factors in gout that were associated with metabolic syndrome, a multivariate analysis was done. The age-adjusted prevalence of metabolic syndrome in gout patients was 43.6%, which was significantly higher than that of the Korean control population (5.2%) from the previous studies. Patients with gout had more components of metabolic syndrome than did the controls. Body mass index (BMI, OR = 1.357 (95%CI 1.111-1.657)) and high density lipoprotein (HDL, OR = 0.774 (95%CI 0.705-0.850)) were the variables most significantly associated with the occurrence of metabolic syndrome in gout, but alcohol consumption did not show such associations. Gout is associated with the metabolic syndrome, and furthermore, obesity and dyslipidemia were the factors most associated with the syndrome in these patients.
有人提出，高尿酸血症以及可能的痛风与代谢综合征有关，但尚无直接研究。本研究旨在了解痛风患者中代谢综合征的患病率，并将其与一般人群研究中的患病率进行比较。这是一项由4家机构参与的病例对照研究，共纳入168例痛风患者。我们根据ATP III标准评估代谢综合征的患病率，并将其与历史对照的患病率进行比较。为了阐明痛风中与代谢综合征相关的因素，我们进行了多变量分析。痛风患者经年龄调整后的代谢综合征患病率为43.6%，显著高于先前研究中的韩国对照人群（5.2%）。痛风患者比对照组有更多的代谢综合征组成成分。体重指数（BMI，OR = 1.357（95%CI 1.111 - 1.657））和高密度脂蛋白（HDL，OR = 0.774（95%CI 0.705 - 0.850））是与痛风患者代谢综合征发生最显著相关的变量，但饮酒未显示出这种相关性。痛风与代谢综合征有关，此外，肥胖和血脂异常是这些患者中与该综合征最相关的因素。
