Department of Chemistry, University at Albany, SUNY, 1400 Washington Ave., Albany, NY 12222, USA.
Chem Commun (Camb). 2010 Oct 14;46(38):7154-6. doi: 10.1039/c0cc02423f. Epub 2010 Sep 1.
The controlled reversal of supramolecular helical chirality in protein fibrils is reported for the first time. Normal or reversed insulin fibrils were grown by precise adjustment of pH. AFM images show two polymorphs corresponding to opposite senses of helical twist of the supramolecular structure with the same cross-β-sheet core.
首次报道了在蛋白质原纤维中控制超分子螺旋手性反转。通过精确调节 pH 值来生长正常或反转的胰岛素原纤维。原子力显微镜图像显示了两种多晶型物，它们对应于超分子结构的螺旋扭转的相反手性，具有相同的交叉-β-折叠核心。
