Universidad Complutense de Madrid, Departamento de Anatomía y Embriología Humana I, Madrid, Spain.
Clin Anat. 2010 Sep;23(6):673-82. doi: 10.1002/ca.20956.
The presence of ganglia associated with the laryngeal nerves is well documented. In man, these ganglia have been less well studied than in other species and, in particular, the cell types within these ganglia are less well characterized. Using a panel of antibodies to a variety of markers found in the paraganglion cells of other species, we were able to show the existence of at least two populations of cells within human laryngeal paraganglia. One population contained chromogranin and tyrosine hydroxylase representing a neurosecretory population possibly secreting dopamine. A second population of choline acetyltransferase positive cells would appear to have a putative parasympathetic function. Further work is needed to characterize these cell populations more fully before it will be possible to assign functions to these cell types but our results are consistent with the postulated functions of these ganglia as chemoreceptors, neurosecretory cells, and regulators of laryngeal mucus secretion.
神经节与喉返神经相关的存在已有充分的文献记载。在人类中，这些神经节的研究不如其他物种充分，特别是这些神经节内的细胞类型的特征描述得较少。使用一组针对其他物种副节细胞中发现的多种标志物的抗体，我们能够证明人类喉副节中至少存在两种细胞群体。一种群体包含嗜铬粒蛋白和酪氨酸羟化酶，代表可能分泌多巴胺的神经分泌群体。第二群胆碱乙酰转移酶阳性细胞似乎具有假定的副交感功能。在有可能将这些细胞类型的功能分配之前，需要进一步的工作来更全面地描述这些细胞群体，但我们的结果与这些神经节作为化学感受器、神经分泌细胞和调节喉粘液分泌的假设功能一致。
