中国 11 个城市人体血液中合成麝香香料的出现情况。

Occurrence of synthetic musk fragrances in human blood from 11 cities in China.

机构信息

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P. O. Box 2871, Beijing, 100085, People's Republic of China.

出版信息

Environ Toxicol Chem. 2010 Sep;29(9):1877-82. doi: 10.1002/etc.258.

DOI:10.1002/etc.258

PMID:20821644

Abstract

We measured two nitro musk fragrances (musk xylene) and musk ketone) and five polycyclic musk fragrances (galaxolide [HHCB], tonalide [AHTN], celestolide [ADBI], traseolide [ATII], and phantolide [AHMI]) in human blood samples from 11 cities of China (n = 204). Possible temporal trends in musk concentrations and associations with personal factors, such as gender, age, and others, were studied. Galaxolide (HHCB) showed the highest median concentration (0.85 ng/g) followed by AHTN (0.53 ng/g) with high detection frequency (91 and 77%, respectively). Concentrations of the other synthetic musk fragrances, including musk ketone and musk xylene, were all below the quantification limits. The results suggested that musk concentrations were not significantly relative to gender and body weight but positively correlated with age groups and locations. Apparent differences were also observed in the ratios of HHCB to AHTN concentrations among different cities.

摘要

我们在中国 11 个城市的 204 个人血样本中测量了两种硝基麝香香料（二甲苯麝香）和麝香酮）和五种多环麝香香料（HHCB（加乐麝香）、AHTN（吐纳麝香）、ADBI（仙乐麝香）、ATII（特乐麝香）和 AHMI（海因麝香））。研究了麝香浓度的可能时间趋势以及与个人因素（如性别、年龄等）的关系。HHCB（加乐麝香）的浓度最高（中位数为 0.85ng/g），其次是 AHTN（0.53ng/g），检出率均较高（分别为 91%和 77%）。其他合成麝香香料（包括麝香酮和二甲苯麝香）的浓度均低于定量限。结果表明，麝香浓度与性别和体重无关，但与年龄组和地点呈正相关。不同城市 HHCB 与 AHTN 浓度比值也存在明显差异。