人体样本中新型污染物暴露生物标志物的测定方法。
Methods for the determination of biomarkers of exposure to emerging pollutants in human specimens.
作者信息
Yusa Vicent, Ye Xiaoyun, Calafat Antonia M
机构信息
Public Health Research Center of Valencia (CSISP), Av. Catalunya, 21, 46020, Valencia, Spain.
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA, USA.
出版信息
Trends Analyt Chem. 2012 Sep;38:129-142. doi: 10.1016/j.trac.2012.05.004.
Abstract
Biomonitoring is a very useful tool for assessing human exposure to environmental pollutants. This review discusses recent methods for the quantitative measurement of biomarkers of exposure to different classes of chemicals used in personal-care products (e.g., musk fragrances, preservatives, UV filters, and insect repellents) and consumer products (e.g., organophosphate flame retardants, phthalate esters, perfluorinated compounds, and industrial phenols). The measurements are mainly taken in urine, blood, and breast milk. We also discuss the different procedures commonly used for sample-pretreatment, extraction, and clean up, and chromatographic techniques currently used to determine these compounds. Finally, we present data on the main biomarkers occurring in different human specimens.
摘要
生物监测是评估人类接触环境污染物的一项非常有用的工具。本综述讨论了用于定量测量个人护理产品（如麝香香料、防腐剂、紫外线过滤剂和驱虫剂）及消费品（如有机磷酸酯阻燃剂、邻苯二甲酸酯、全氟化合物和工业酚类）中不同类别化学品暴露生物标志物的最新方法。测量主要在尿液、血液和母乳中进行。我们还讨论了样品预处理、提取和净化常用的不同程序，以及目前用于测定这些化合物的色谱技术。最后，我们展示了不同人体样本中主要生物标志物的数据。
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