Division of Material Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan.
Org Lett. 2010 Oct 1;12(19):4341-3. doi: 10.1021/ol101763w.
A new method for the highly effective synthesis of α-siloxyamides is described. The addition of isocyanide to aldehyde proceeded smoothly in the presence of silanol to give the corresponding α-siloxyamides in high yields. A wide range of aldehydes and isocyanides are applicable in this reaction.
描述了一种高效合成α-硅氧基酰胺的新方法。在硅醇存在下，异氰化物与醛加成反应顺利进行，以高产率得到相应的α-硅氧基酰胺。该反应适用于各种醛和异氰化物。
