Maringhini Silvio, Corrado Ciro, Maringhini Guido, Cusumano Rosa, Azzolina Vitalba, Leone Francesco
Paediatric Nephrology Unit, G. Di Cristina Children's Hospital, A.R.N.A.S. Civico, Di Cristina, Fatebenefratelli, Palermo, Italy.
J Matern Fetal Neonatal Med. 2010 Oct;23 Suppl 3:84-6. doi: 10.3109/14767058.2010.510245.
Observational studies in humans and experimental studies in animals have clearly shown that renal failure may start early in life. 'Fetal programming' is regulated by adaptations occurring in uterus including maternal nutrition, placental blood supply, and epigenetic changes. Low birth weight predisposes to hypertension and renal insufficiency. Congenital abnormalities of the kidney and urinary tract, adverse postnatal events, wrong nutritional habits may produce renal damage that will become clinically relevant in adulthood. Prevention should start early in children at risk of renal disease.
对人类的观察性研究和对动物的实验性研究均已清楚表明，肾衰竭可能在生命早期就开始。“胎儿编程”受子宫内发生的适应性变化调节，包括母体营养、胎盘血液供应和表观遗传变化。低出生体重易引发高血压和肾功能不全。肾脏和尿路的先天性异常、不良的出生后事件、错误的营养习惯可能导致肾脏损伤，而这种损伤在成年后会变得具有临床相关性。对于有患肾病风险的儿童，预防应尽早开始。
