EA 4466 Stress cellulaire: physiopathologie, stratégies nutritionnelles et innovations thérapeutiques, Faculté de Pharmacie Paris Descartes, hôpital Charles Foix, APHP, Paris, France.
Curr Opin Clin Nutr Metab Care. 2010 Nov;13(6):729-36. doi: 10.1097/MCO.0b013e32833ef291.
The metabolic syndrome is associated with increased risk for development of both cardiovascular disease and type 2 diabetes in humans. Because experimental data and clinical experience have shown that metabolic syndrome and caloric restriction have, at least partly, opposite pathophysiological pathways, the activation of sirtuins may constitute a pharmacological approach to treat metabolic syndrome. Resveratrol is a polyphenol produced by plants that has multiple beneficial activities similar to those associated with caloric restriction.
Through its regulatory action of both AMP kinase and the sirtuin sirtuin-1, resveratrol is a natural sirtuin activator that certainly will be the head of a new pharmacological family of drugs targeted on sirtuin-1 activity exacerbation in order to treat/protect from obesity and diabetes, and thus metabolic syndrome.
This review discusses the therapeutic use of resveratrol and sirtuin activators in the context of insulin resistance and obesity, the two main features of metabolic syndrome.
代谢综合征与人类心血管疾病和 2 型糖尿病的发展风险增加有关。由于实验数据和临床经验表明，代谢综合征和热量限制至少在部分上具有相反的病理生理途径，因此激活沉默信息调节因子可能构成治疗代谢综合征的一种药理学方法。白藜芦醇是一种植物多酚，具有多种类似于热量限制相关的有益活性。
通过对 AMP 激酶和沉默信息调节因子 1 的调节作用，白藜芦醇是一种天然的沉默信息调节因子激活剂，它肯定将成为以沉默信息调节因子 1 活性增强为靶点的新型药物家族的领头羊，以治疗/预防肥胖和糖尿病，从而治疗代谢综合征。
本文讨论了白藜芦醇和沉默信息调节因子激活剂在胰岛素抵抗和肥胖（代谢综合征的两个主要特征）背景下的治疗用途。
