Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, #123, Ta-Pei Road, Niao-Sung District, Kaohsiung, Taiwan.
Lipids Health Dis. 2020 Jul 25;19(1):174. doi: 10.1186/s12944-020-01349-w.
Maternal obesity is an emerging problem in the modern world. Growing evidence suggests that intrauterine high-fat (HF) exposure may predispose progeny to subsequent metabolic challenges. Progeny born to mothers who ate an HF diet also tends to eat an HF diet when growing and aggravate metabolic issues. Thus, the generational transmission of obesity is cyclical. Developing a strategy to prevent the occurrence of metabolic syndrome related to prenatal and/or postnatal HF diet is important. In this study, the reprogramming effects of maternal resveratrol treatment for the progeny with maternal HF/postnatal HF diets were investigated.
Sprague-Dawley dams were fed either a control or a high-fat/high sucrose diet (HFHS) from mating to lactation. After weaning, the progeny was fed chow or an HF diet. Four experimental groups were yielded: CC (maternal/postnatal control diet), HC (maternal HF/postnatal control diet), CH (maternal control/postnatal HFHS diet), and HH (maternal/postnatal HFHS diet). A fifth group (HRH) received a maternal HFHS diet plus maternal resveratrol treatment and a postnatal chow diet to study the effects of maternal resveratrol therapy.
Maternal resveratrol treatment lessened the weight and adiposity of progeny that were programmed by combined prenatal and postnatal HFHS diets. Maternal resveratrol therapy ameliorated the decreased abundance of the sirtuin 1 (SIRT1) enzyme in retroperitoneal tissue and the altered leptin/soluble leptin receptor ratio of progeny. Maternal resveratrol therapy also decreased lipogenesis and increased lipolysis for progeny.
Maternal resveratrol intervention can prevent adiposity programmed by maternal and postnatal HFHS diets by inducing lipid metabolic modulation. This study offers a novel reprogramming role for the effect of maternal resveratrol supplements against obesity.
母体肥胖是现代社会出现的一个问题。越来越多的证据表明，宫内高脂肪（HF）暴露可能使后代易患随后的代谢挑战。从吃 HF 饮食的母亲那里出生的后代在成长过程中也倾向于吃 HF 饮食，并加重代谢问题。因此，肥胖的代际传递是循环的。制定一种策略来预防与产前和/或产后 HF 饮食相关的代谢综合征的发生是很重要的。在这项研究中，研究了母体白藜芦醇治疗对母体 HF/产后 HF 饮食后代的重编程作用。
从交配到哺乳期，Sprague-Dawley 母鼠分别喂食对照或高脂肪/高蔗糖饮食（HFHS）。断奶后，后代喂食标准饲料或 HF 饮食。产生了四个实验组：CC（母体/产后对照饮食）、HC（母体 HF/产后对照饮食）、CH（母体对照/产后 HFHS 饮食）和 HH（母体/产后 HFHS 饮食）。第五组（HRH）接受母体 HFHS 饮食加母体白藜芦醇治疗和产后标准饮食，以研究母体白藜芦醇治疗的效果。
母体白藜芦醇治疗减轻了由产前和产后 HFHS 饮食联合编程的后代的体重和肥胖程度。母体白藜芦醇治疗改善了后代腹膜后组织中沉默调节蛋白 1（SIRT1）酶的丰度降低和瘦素/可溶性瘦素受体比值改变。母体白藜芦醇治疗还降低了后代的脂肪生成并增加了脂肪分解。
母体白藜芦醇干预可以通过诱导脂质代谢调节来预防由母体和产后 HFHS 饮食编程的肥胖。这项研究为母体白藜芦醇补充剂对肥胖的重编程作用提供了一个新的观点。
