Sadruddin Sarfaraz, Arora Rohit
Department of Medicine, Chicago Medical School, North Chicago, IL 60064, USA.
J Cardiometab Syndr. 2009 Spring;4(2):102-6. doi: 10.1111/j.1559-4572.2008.00039.x.
Resveratrol (3,4',5 trihydroxystilbene), a naturally-occurring molecule known as a phytoalexin, is synthesized by plants in response to attacks by fungi, bacteria, or other injurious substances; it is also known to possess an array of cardioprotective effects. Recently, studies have shown resveratrol to protect against the metabolic changes associated with hypercaloric diets in mice with induced insulin resistance, hyperglycemia, and dyslipidemia. Despite impressive gains in diagnosis and treatment, cardiovascular disease (CVD) remains a serious clinical problem and threat to public health. The metabolic syndrome, which identifies persons at higher risk for diabetes mellitus and CVD, is approaching a prevalence of nearly 25% of the western world. If the metabolic syndrome can be considered a polar opposite to caloric restriction, then agents that mimic caloric restriction may offer a new therapeutic approach to preventing CVD. The authors discuss the cardioprotective effects of resveratrol and highlight its role in glucose homeostasis and lipid metabolism in mice. Armed with the ability to prevent the deleterious effects of excess caloric intake and prevent detrimental cardiovascular events, resveratrol merits proper clinical investigations for its efficacy in treating metabolic diseases and CVD.
白藜芦醇（3,4',5-三羟基茋）是一种天然存在的分子，被称为植物抗毒素，由植物在受到真菌、细菌或其他有害物质攻击时合成；它还具有一系列心脏保护作用。最近，研究表明白藜芦醇可保护诱导胰岛素抵抗、高血糖和血脂异常的小鼠免受与高热量饮食相关的代谢变化影响。尽管在诊断和治疗方面取得了令人瞩目的进展，但心血管疾病（CVD）仍然是一个严重的临床问题，对公众健康构成威胁。代谢综合征可识别出患糖尿病和心血管疾病风险较高的人群，在西方世界的患病率接近25%。如果代谢综合征可被视为与热量限制截然相反的情况，那么模拟热量限制的药物可能为预防心血管疾病提供一种新的治疗方法。作者讨论了白藜芦醇的心脏保护作用，并强调了其在小鼠葡萄糖稳态和脂质代谢中的作用。鉴于白藜芦醇有能力预防热量摄入过多的有害影响并预防有害的心血管事件，其在治疗代谢性疾病和心血管疾病方面的疗效值得进行适当的临床研究。
