血清镁与动脉粥样硬化风险社区研究（ARIC）中心律失常性猝死的风险。
Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study.
机构信息
University of Minnesota, Minneapolis, 55454, USA.
出版信息
Am Heart J. 2010 Sep;160(3):464-70. doi: 10.1016/j.ahj.2010.06.012.
BACKGROUND
We hypothesized that serum magnesium (Mg) is associated with increased risk of sudden cardiac death (SCD).
METHODS
The Atherosclerosis Risk in Communities Study assessed risk factors and levels of serum Mg in a cohort of 45- to 64-year-old subjects in 1987-1989 (n = 14,232). After an average of 12 years of follow-up, we observed 264 cases of SCD, as determined by physician review of all suspected cases. We used proportional hazards regression to evaluate the association of serum Mg with risk of SCD.
RESULTS
Individuals in the highest quartile of serum Mg were at significantly lower risk of SCD in all models. This association persisted after adjustment for potential confounding variables, with an almost 40% reduced risk of SCD (hazard ratio 0.62, 95% CI 0.42-0.93) in quartile 4 versus 1 of serum Mg observed in the fully adjusted model.
CONCLUSIONS
This study suggests that low levels of serum Mg may be an important predictor of SCD. Further research into the effectiveness of Mg supplementation for those considered to be at high risk for SCD is warranted.
背景
我们假设血清镁（Mg）与心脏性猝死（SCD）风险增加有关。
方法
社区动脉粥样硬化风险研究（Atherosclerosis Risk in Communities Study）评估了 1987-1989 年 45 至 64 岁人群队列中的危险因素和血清 Mg 水平（n = 14232）。在平均 12 年的随访后，我们观察到了 264 例 SCD，这些病例是通过医生对所有疑似病例的审查确定的。我们使用比例风险回归来评估血清 Mg 与 SCD 风险之间的关联。
结果
在所有模型中，血清 Mg 最高四分位数的个体 SCD 风险显著降低。在调整了潜在混杂变量后，这种关联仍然存在，在完全调整的模型中，与血清 Mg 第 1 四分位数相比，第 4 四分位数的 SCD 风险降低近 40%（危险比 0.62，95%CI 0.42-0.93）。
结论
本研究表明，低水平的血清 Mg 可能是 SCD 的一个重要预测因素。对于那些被认为有发生 SCD 高风险的人，进一步研究 Mg 补充剂的有效性是有必要的。
Zotero 插件