Fujita K, Yoshioka H, Sakata H, Murono K, Kakehashi H, Kaeriyama M, Tsukamoto T
Department of Pediatrics, Asahikawa Medical College, Japan.
Acta Paediatr Jpn. 1990 Dec;32(6):610-4. doi: 10.1111/j.1442-200x.1990.tb00894.x.
K1 antigens, serotypes and antibiotic susceptibilities of Escherichia coli isolates from neonates and infants were investigated. The presence of K1 antigen was tested by the K1-specific phage method. The number of K1 positive strains was 27 (84%) of 32 isolates from cerebrospinal fluid, 11 (25%) of 44 from blood and 4 (22%) of 18 from other specimens. Fourteen (33%) of the K1 positive strains were serotyped as O16:H6, and 8, 7 and 5 were serotyped as O18ac:H7, O1:H7 and O7:H-, respectively. One of 5 of the K1 negative strains were distributed into 30 different combinations of O and H antigens. The ampicillin resistance rates were 19% in K1 positive strains and 45% in K1 negative ones. The incidence of chloramphenicol resistance was the same in K1 positive and negative strains (21%). Ampicillin resistance was not noted in O16:H6 strains, but the incidence of antibiotic resistance was high (65% to ampicillin and 53% to chloramphenicol) in the rough-type strains.
对从新生儿和婴儿中分离出的大肠杆菌的K1抗原、血清型及抗生素敏感性进行了研究。采用K1特异性噬菌体方法检测K1抗原的存在情况。来自脑脊液的32株分离菌中，K1阳性菌株有27株（84%）；来自血液的44株中，有11株（25%）；来自其他标本的18株中，有4株（22%）。14株（33%）K1阳性菌株血清型为O16:H6，8株、7株和5株分别血清型为O18ac:H7、O1:H7和O7:H-。5株K1阴性菌株中的1株分布于30种不同的O和H抗原组合中。K1阳性菌株的氨苄西林耐药率为19%，K1阴性菌株为45%。K1阳性和阴性菌株的氯霉素耐药发生率相同（21%）。O16:H6菌株未发现氨苄西林耐药，但粗糙型菌株的抗生素耐药发生率较高（氨苄西林耐药率为65%，氯霉素耐药率为53%）。
