Nimmich W, Zingler G
Z Urol Nephrol. 1984 Jun;77(6):343-9.
Following introductory remarks on the typing antigens of E. coli and the relation between O:K:H serotypes and urinary tract infections (UTI), the importance of fimbriae as adhesive factors for the pathogenesis of UTI is pointed out. Our own results on the haemagglutination (HA) patterns and the establishing of fimbrial (F) antigens in E. coli strains from patients with UTI are presented. 42 O1:K2 strains were examined for the presence of F-antigens using crossed immunoelectrophoresis. In 31 strains with mannose-resistant HA from human and monkey erythrocytes this characteristically correlated with the presence of F-antigen. A close relation between O:K:H serotypes and F-antigen was found. In twelve O1:K1:H7 strains and five immobile variants of this serotype we succeeded in identifying the F11 antigen. 14 strains of the serotype O1:K1:H- had the F9 antigen. It is assumed that O1:K1:H7:F11 (incl. O1:K1:H-:F11-) strains and O:1:K1:H-:F9 isolates are derived from different clones.
在对大肠杆菌的分型抗原以及O:K:H血清型与尿路感染(UTI)之间的关系进行介绍性阐述之后,指出了菌毛作为UTI发病机制中黏附因子的重要性。展示了我们自己关于UTI患者大肠杆菌菌株血凝(HA)模式及菌毛(F)抗原确立的研究结果。使用交叉免疫电泳对42株O1:K2菌株进行F抗原检测。在31株对人和猴红细胞具有甘露糖抗性HA的菌株中,这一特性与F抗原的存在显著相关。发现O:K:H血清型与F抗原之间存在密切关系。在12株O1:K1:H7菌株及该血清型的5个不运动变异株中,我们成功鉴定出F11抗原。14株O1:K1:H-血清型菌株具有F9抗原。推测O1:K1:H7:F11(包括O1:K1:H-:F11-)菌株和O:1:K1:H-:F9分离株源自不同克隆。