安卡菲德止血剂®在实验性肝创伤模型中预防实质出血的能力。
Ability of the ankaferd blood stopper® to prevent parenchymal bleeding in an experimental hepatic trauma model.
作者信息
Aysan Erhan, Bektas Hasan, Ersoz Feyzullah, Sari Serkan, Kaygusuz Arslan, Huq Gulben Erdem
机构信息
Istanbul Educational and Research Hospital, Department of General Surgery Istanbul, Turkey.
出版信息
Int J Clin Exp Med. 2010 Jun 30;3(3):186-91.
UNLABELLED
Hepatic parenchymal bleeding (HPB) is a major problem following both trauma and elective hepatic procedures. The present study investigated the effect of the Ankaferd Blood Stopper® (ABS) on HPB.
METHOD(S): A total of 20 rats were used. After creating a laceration model in the left lateral hepatic lobe, the area was compressed for 3 minutes with the ABS in the rats in group 1 (n=10) and with 0.9% NaCl-soaked gauze in the rats in group 2 (n=10).
RESULTS
The mean change in haematocrit levels between baseline and the 24 hour values in group 1 was lower than group 2 (p=0.045). The mean perioperative bleeding in group 1 was lower than group 2 (p=0.003). The histopa-thologic evaluation revealed that there were no differences between the groups with respect to areas of necrosis (p=0.107) or inflammation (p=0.135).
CONCLUSION
Although the ABS does not stop HPB completely, it ensures a statistically significant reduction in HPB.
未标注
肝实质出血（HPB）是创伤和择期肝脏手术后的一个主要问题。本研究调查了安卡非德止血剂（ABS）对肝实质出血的影响。
方法
总共使用了20只大鼠。在左侧肝叶建立撕裂伤模型后，第1组（n = 10）的大鼠用ABS对该区域压迫3分钟，第2组（n = 10）的大鼠用浸有0.9%氯化钠的纱布压迫。
结果
第1组血细胞比容水平在基线和24小时值之间的平均变化低于第2组（p = 0.045）。第1组围手术期平均出血量低于第2组（p = 0.003）。组织病理学评估显示，两组在坏死面积（p = 0.107）或炎症（p = 0.135）方面没有差异。
结论
尽管ABS不能完全止住肝实质出血，但它能在统计学上显著减少肝实质出血。
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