Department of Pediatric Hematology, Yuzuncu Yil University, Van, Turkey.
Clin Appl Thromb Hemost. 2011 Nov-Dec;17(6):E36-8. doi: 10.1177/1076029610382104. Epub 2010 Sep 9.
Hematologic abnormalities of mild anemia and leucopenia have been frequently associated with acute brucellosis, but thrombocytopenia are less frequently seen. In the present study, we documented 5 (2.6%) isolated thrombocytopenic patients with the manifestations of brucellosis observed during the course of active infection. Five (2.6%) patients, 4 boys and 1 girl, with ages ranging from 2 to 14 years, had isolated thrombocytopenic at diagnosis. In 5 (2.6%) patients, platelet counts ranged from 39,000 to 120,000/mm(3). Tube agglutination tests for brucellosis were positive for all patients (1/160-1/1280). All patients recovered completely, and their thrombocytopenia returned to normal by 2 to 4 weeks after antibiotic treatment of brucellosis. In our study, we present 5 patients with Brucella-induced thrombocytopenia mimicking idiopathic thrombocytopenic purpura to emphasize the isolated thrombocytopenia and the resolution of thrombocyte counts following treatment of brucellosis.
轻度贫血和白细胞减少症的血液学异常常与急性布鲁氏菌病有关，但血小板减少症则较少见。在本研究中，我们记录了 5 例（2.6%）表现为布鲁氏菌病的孤立性血小板减少症患者，这些患者在活动性感染期间观察到。5 例（2.6%）患者，男 4 例，女 1 例，年龄 2 至 14 岁，诊断时即存在孤立性血小板减少症。在 5 例（2.6%）患者中，血小板计数范围为 39,000 至 120,000/mm3。所有患者的试管凝集试验均对布鲁氏菌病呈阳性（1/160-1/1280）。所有患者均完全康复，且在接受布鲁氏菌病抗生素治疗后 2 至 4 周内血小板减少症恢复正常。在我们的研究中，我们提出了 5 例布鲁氏菌引起的血小板减少症患者，这些患者的表现类似于特发性血小板减少性紫癜，以强调孤立性血小板减少症以及在治疗布鲁氏菌病后血小板计数的恢复。
