Dressler C, Dauberschmidt R
Klinik für Anästhesiologie und Intensivmedizin des Städtischen Krankenhauses im Friedrichshain, Berlin.
Anaesthesiol Reanim. 1990;15(6):351-7.
Under standardized conditions in 102 patients the necessity and the efficiency of human albumin addition in the postoperative phase following abdominal and vascular operations was examined by measuring the colloid osmotic pressure in plasma (COPp). After vascular operations in 3 of the patients (8.6%) and after abdominal operations in 49 of the patients (73.1%) human albumin had to be substituted. During aseptic courses 3 hours and 24 hours after substitution with 5% or 20% solutions of human albumin significant increase of COPp was measured compared to the initial values. Since in septic courses a positive effect of human albumin addition using a 5% solution is uncertain and because the hereby necessary addition of relatively large fluid volume increases the danger of an "overload", only 20% solutions of human albumin should be used in such cases if indicated.
在标准化条件下，对102例患者进行研究，通过测量血浆胶体渗透压（COPp）来检验腹部和血管手术后的术后阶段补充人白蛋白的必要性和有效性。血管手术后，3例患者（8.6%）需要补充人白蛋白；腹部手术后，49例患者（73.1%）需要补充。在使用5%或20%人白蛋白溶液替代后的无菌过程中，与初始值相比，3小时和24小时后COPp显著升高。由于在感染过程中，使用5%溶液补充人白蛋白的积极效果不确定，且由此需要补充相对大量的液体增加了“超负荷”的风险，因此在这种情况下，如果有指征，仅应使用20%的人白蛋白溶液。
