韩国妊娠期糖尿病女性 2 型糖尿病的家族聚集性。
Familial clustering of type 2 diabetes in Korean women with gestational diabetes mellitus.
机构信息
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.
出版信息
Korean J Intern Med. 2010 Sep;25(3):269-72. doi: 10.3904/kjim.2010.25.3.269. Epub 2010 Aug 31.
Abstract
BACKGROUND/AIMS: This study was conducted to examine the relationship between family history of type 2 diabetes (T2DM) and risk of developing gestational diabetes mellitus (GDM) in Korean women.
METHODS
We performed a 100-g oral glucose tolerance test in 858 pregnant women who had abnormal glucose tolerance in 50-g oral glucose challenge. In addition, we reviewed the incidence of T2DM in the parents and siblings and analyzed the association between the familial history of T2DM and the risk of GDM.
RESULTS
Of the 858 subjects, 427 were normal, and 431 were diagnosed with GDM. Compared with women with no family history of T2DM, women with first degree family history of T2DM displayed higher risk of T2DM (odd ratio: parent only 1.91, sibling only 6.24, any 2.27).
CONCLUSIONS
The risk of developing GDM was significantly increased in Korean women with a family history of T2DM in first-degree relatives.
摘要
背景/目的：本研究旨在探讨韩国女性 2 型糖尿病（T2DM）家族史与妊娠糖尿病（GDM）发病风险之间的关系。
方法
我们对 858 例糖耐量异常的孕妇进行了 100g 口服葡萄糖耐量试验。此外，我们还回顾了父母和兄弟姐妹的 T2DM 发病率，并分析了 T2DM 家族史与 GDM 发病风险之间的关系。
结果
在 858 例受试者中，427 例血糖正常，431 例诊断为 GDM。与无 T2DM 家族史的女性相比，一级亲属有 T2DM 家族史的女性发生 T2DM 的风险更高（比值比：父母一方仅为 1.91，兄弟姐妹仅为 6.24，任意一方为 2.27）。
结论
在韩国女性中，一级亲属有 T2DM 家族史的女性发生 GDM 的风险显著增加。
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