Harder T, Franke K, Kohlhoff R, Plagemann A
Institute of Experimental Endocrinology, Humboldt University Medical School (Charité), Schumannstrasse 20/21, D-10098 Berlin, Germany.
Gynecol Obstet Invest. 2001;51(3):160-4. doi: 10.1159/000052916.
Animal studies have shown that prenatal exposure to a diabetic intrauterine milieu leads to an increased risk in the female offspring of developing gestational diabetes (GD). In the present study, the family history of non-insulin-dependent diabetes mellitus type II (NIDDM) and insulin-dependent diabetes mellitus type I (IDDM) was evaluated in 106 women with GD, as compared to 189 women with IDDM. In GD patients, the prevalence of diabetes was significantly greater in mothers than in fathers (p = 0.03). This was mainly due to a greater prevalence of NIDDM in the mothers (p = 0.05). Furthermore, a significant aggregation of NIDDM was also observed in the maternal-grandmaternal line of GD women, as compared to the paternal-grandpaternal side (p = 0.02). In patients with IDDM no significant difference concerning the prevalence of any type of diabetes between mothers and fathers was observed. In conclusion, an aggregation of NIDDM in mothers and grandmothers of women with GD is reported here. A history of NIDDM on the maternal side of pregnant women should be considered as a particular risk factor for GD and, hence, for intergenerative transmission of NIDDM, which therefore might be prevented, at least in part, by strict avoidance of GD.
动物研究表明，孕期暴露于糖尿病子宫内环境会增加雌性后代患妊娠期糖尿病（GD）的风险。在本研究中，对106例GD女性以及189例1型糖尿病（IDDM）女性的非胰岛素依赖型2型糖尿病（NIDDM）和胰岛素依赖型1型糖尿病（IDDM）家族史进行了评估。在GD患者中，母亲患糖尿病的患病率显著高于父亲（p = 0.03）。这主要是由于母亲中NIDDM的患病率更高（p = 0.05）。此外，与父系-祖父系相比，在GD女性的母系-外祖母系中也观察到NIDDM的显著聚集（p = 0.02）。在IDDM患者中，未观察到母亲和父亲之间任何类型糖尿病患病率的显著差异。总之，本文报道了GD女性的母亲和祖母中NIDDM的聚集情况。孕妇母系有NIDDM病史应被视为GD的一个特殊危险因素，因此也是NIDDM代际传播的危险因素，因此至少部分可以通过严格避免GD来预防。
