Royal Free Hospital, Royal Free Hampstead NHS Trust, London, UK.
Clin Exp Dermatol. 2010 Oct;35(7):699-705. doi: 10.1111/j.1365-2230.2010.03851.x.
Cutaneous leishmaniasis is one of the most common tropical dermatoses worldwide and is of major public health importance. It is caused by numerous Leishmania protozoa species, which are responsible for its clinical diversity. With changes in vector (sandfly) habitat and increased travel among human populations, its incidence is rising, and in nonendemic countries, including the UK, it is increasingly diagnosed in migrants, returned travellers, and military personnel. Diagnostic tests have not always been sufficiently sensitive, and despite a wide range of treatments, poor therapeutic responses and adverse effects are common. In the past decade, there have been notable advances in molecular diagnostics, in the understanding of host immune responses to infection, and in new therapeutic interventions and vaccine development.
皮肤利什曼病是全球最常见的热带皮肤病之一，具有重要的公共卫生意义。它是由多种利什曼原虫引起的，这也是其临床表现多样的原因。随着媒介（沙蝇）栖息地的变化和人类之间旅行的增加，其发病率正在上升，在包括英国在内的非流行国家，移民、归国旅行者和军人中越来越多地被诊断出患有这种疾病。诊断检测并不总是足够敏感，尽管有多种治疗方法，但治疗反应不佳和不良反应很常见。在过去十年中，在分子诊断、宿主对感染的免疫反应以及新的治疗干预措施和疫苗开发方面取得了显著进展。
