CD23/FcεRII：分子的多任务处理。
CD23/FcεRII: molecular multi-tasking.
机构信息
Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, CR-UK Beatson Institute, Glasgow, UK.
出版信息
Clin Exp Immunol. 2010 Oct;162(1):12-23. doi: 10.1111/j.1365-2249.2010.04210.x.
Abstract
CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.
摘要
CD23 是免疫球蛋白 (Ig)E 的低亲和力受体，在 IgE 反应的调节中发挥重要作用。CD23 可以从细胞表面被切割，产生一系列具有多种细胞因子样活性的可溶性 CD23（sCD23）蛋白。负责与许多已知配体（包括 IgE、CD21、主要组织相容性复合体 (MHC) Ⅱ类和整合素）相互作用的 CD23 区域已被确定，有助于解释 CD23 蛋白的结构-功能关系。CD23 的转化研究强调了它作为治疗干预策略的靶标可信度，并说明了它在介导针对其他靶标的抗体的治疗效果中的作用。
相似文献
1
CD23/FcεRII: molecular multi-tasking.CD23/FcεRII：分子的多任务处理。
Clin Exp Immunol. 2010 Oct;162(1):12-23. doi: 10.1111/j.1365-2249.2010.04210.x.
2
Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.钙离子依赖的 B 细胞受体 CD23 结构变化增加了其与人免疫球蛋白 E 的亲和力。
J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.
3
Comparative binding of soluble fragments (derCD23, sCD23, and exCD23) of recombinant human CD23 to CD21 (SCR 1-2) and native IgE, and their effect on IgE regulation.比较重组人 CD23 的可溶性片段（derCD23、sCD23 和 exCD23）与 CD21（SCR 1-2）和天然 IgE 的结合，并研究它们对 IgE 调节的影响。
Cell Immunol. 2011;271(2):371-8. doi: 10.1016/j.cellimm.2011.08.003. Epub 2011 Aug 12.
4
Soluble CD21 (sCD21) forms biologically active complexes with CD23: sCD21 is present in normal plasma as a complex with trimeric CD23 and inhibits soluble CD23-induced IgE synthesis by B cells.可溶性CD21（sCD21）与CD23形成生物活性复合物：sCD21在正常血浆中以与三聚体CD23的复合物形式存在，并抑制可溶性CD23诱导的B细胞IgE合成。
Int Immunol. 1998 Oct;10(10):1459-66. doi: 10.1093/intimm/10.10.1459.
5
The structure of human CD23 and its interactions with IgE and CD21.人类CD23的结构及其与IgE和CD21的相互作用。
J Exp Med. 2005 Sep 19;202(6):751-60. doi: 10.1084/jem.20050811.
6
alphavbeta5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein.αvβ5整合素通过与CD23蛋白的一个碱性结构域进行不依赖RGD的相互作用来维持人前B细胞的生长。
J Biol Chem. 2007 Sep 14;282(37):27315-27326. doi: 10.1074/jbc.M609335200. Epub 2007 May 31.
7
Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.IgE 受体相互作用的结构与动力学：FcεRI 和 CD23/FcεRII。
Immunol Rev. 2015 Nov;268(1):222-35. doi: 10.1111/imr.12340.
8
CTLA4Fcε, a novel soluble fusion protein that binds B7 molecules and the IgE receptors, and reduces human in vitro soluble CD23 production and lymphocyte proliferation.CTLA4Fcε，一种新型可溶性融合蛋白，可结合B7分子和IgE受体，并减少人体外可溶性CD23的产生和淋巴细胞增殖。
Immunology. 2016 May;148(1):40-55. doi: 10.1111/imm.12586. Epub 2016 Mar 8.
9
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.人细胞表面受体CD23配体结合域的基于结构的建模及两个独立推导的分子模型的比较
Protein Sci. 1996 Feb;5(2):240-7. doi: 10.1002/pro.5560050207.
10
The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition.人免疫球蛋白E的赖氨酸-352在FcepsilonRII/CD23识别中的重要性。
J Biol Chem. 2004 Aug 20;279(34):35320-5. doi: 10.1074/jbc.M404575200. Epub 2004 Jun 15.
引用本文的文献
1
Decoding the immune microenvironment of secondary chronic myelomonocytic leukemia due to diffuse large B-cell lymphoma with CD19 CAR-T failure by single-cell RNA-sequencing.通过单细胞RNA测序解析弥漫性大B细胞淋巴瘤伴CD19嵌合抗原受体T细胞（CAR-T）治疗失败所致继发性慢性粒单核细胞白血病的免疫微环境
Chin Med J (Engl). 2025 Aug 5;138(15):1866-1881. doi: 10.1097/CM9.0000000000003690. Epub 2025 Jul 7.
2
Effects of sample age and storage temperature on the flow cytometric diagnosis of chronic lymphocytic leukaemia in South Africa.样本年龄和储存温度对南非慢性淋巴细胞白血病流式细胞术诊断的影响
Afr J Lab Med. 2025 May 31;14(1):2688. doi: 10.4102/ajlm.v14i1.2688. eCollection 2025.
3
Structural and Functional Insights Into IgE Receptor Interactions and Disruptive Inhibition.对IgE受体相互作用及干扰性抑制的结构与功能见解
Immunol Rev. 2025 May;331(1):e70031. doi: 10.1111/imr.70031.
4
Vaccine-Induced Anti-IgE Antibodies Neutralize Free IgE but Fail to Bind and Activate Mast Cell-Displayed IgE.疫苗诱导的抗IgE抗体可中和游离IgE，但无法结合并激活肥大细胞表面展示的IgE。
Allergy. 2025 Jul;80(7):1995-2007. doi: 10.1111/all.16530. Epub 2025 Apr 7.
5
Effects of house-cultivated edible bird's nest on immunoglobulin and cytokine release .家燕盏对免疫球蛋白及细胞因子释放的影响
Vet World. 2024 Jun;17(6):1370-1384. doi: 10.14202/vetworld.2024.1370-1384. Epub 2024 Jun 28.
6
A Comparison of Natural and Therapeutic Anti-IgE Antibodies.天然抗IgE抗体与治疗性抗IgE抗体的比较
Antibodies (Basel). 2024 Jul 16;13(3):58. doi: 10.3390/antib13030058.
7
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy.CAR-NKT 细胞在哮喘中的应用：NKT 作为 CAR 治疗有前途的细胞的应用。
Clin Rev Allergy Immunol. 2024 Jun;66(3):328-362. doi: 10.1007/s12016-024-08998-0. Epub 2024 Jul 12.
8
Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage.肝实质细胞动力学的异质性可在化学、物理或病毒损伤后恢复肝组织结构。
Nat Commun. 2024 Feb 10;15(1):1247. doi: 10.1038/s41467-024-45439-0.
9
The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children.发育迟缓儿童中维生素D、白细胞介素-4和白细胞介素-10水平以及CD23+表达与支气管哮喘的关联
Biomedicines. 2023 Sep 15;11(9):2542. doi: 10.3390/biomedicines11092542.
10
The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern.极早产儿血液蛋白质谱的发展遵循一种刻板的演变模式。
Commun Med (Lond). 2023 Aug 2;3(1):107. doi: 10.1038/s43856-023-00338-1.
本文引用的文献
1
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.ADAM10 对于 Notch2 依赖性边缘区 B 细胞发育和体内 CD23 裂解是必需的。
J Exp Med. 2010 Mar 15;207(3):623-35. doi: 10.1084/jem.20091990. Epub 2010 Feb 15.
2
CD23 expression in plasma cell myeloma is specific for abnormalities of chromosome 11, and is associated with primary plasma cell leukaemia in this cytogenetic sub-group.浆细胞骨髓瘤中CD23的表达是11号染色体异常所特有的，并且在这个细胞遗传学亚组中与原发性浆细胞白血病相关。
Br J Haematol. 2010 Apr;149(2):292-3. doi: 10.1111/j.1365-2141.2009.08042.x. Epub 2010 Jan 8.
3
Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes.功能性FCER2启动子多态性与表型相关单倍型的相互作用。
Tissue Antigens. 2009 Dec;74(6):534-8. doi: 10.1111/j.1399-0039.2009.01360.x. Epub 2009 Oct 21.
4
Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.Lumiliximab 联合氟达拉滨、环磷酰胺和利妥昔单抗治疗复发或难治性慢性淋巴细胞白血病的 1/2 期研究。
Blood. 2010 Jan 21;115(3):489-95. doi: 10.1182/blood-2009-08-237727. Epub 2009 Oct 20.
5
CD23 mediates antimycobacterial activity of human macrophages.CD23介导人类巨噬细胞的抗分枝杆菌活性。
Infect Immun. 2009 Dec;77(12):5537-42. doi: 10.1128/IAI.01457-08. Epub 2009 Oct 5.
6
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.抗 TNF 生物制剂：类风湿关节炎的首选治疗方法。
Nat Rev Rheumatol. 2009 Oct;5(10):578-82. doi: 10.1038/nrrheum.2009.181.
7
Predictors of poor response during asthma therapy differ with definition of outcome.哮喘治疗期间不良反应的预测因素因结局定义而异。
Pharmacogenomics. 2009 Aug;10(8):1231-42. doi: 10.2217/pgs.09.86.
8
SDF-1 and PDGF enhance alphavbeta5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines.基质细胞衍生因子-1（SDF-1）和血小板衍生生长因子（PDGF）增强αvβ5介导的细胞外信号调节激酶（ERK）激活以及人前B细胞系的非黏附性生长。
Leukemia. 2009 Oct;23(10):1807-17. doi: 10.1038/leu.2009.126. Epub 2009 Jul 16.
9
Functional and clinical consequences of Fc receptor polymorphic and copy number variants.Fc受体多态性和拷贝数变异的功能及临床后果
Clin Exp Immunol. 2009 Aug;157(2):244-54. doi: 10.1111/j.1365-2249.2009.03980.x.
10
Molecular blocking of CD23 supports its role in the pathogenesis of arthritis.对CD23进行分子阻断支持其在关节炎发病机制中的作用。
PLoS One. 2009;4(3):e4834. doi: 10.1371/journal.pone.0004834. Epub 2009 Mar 12.
Zotero 插件