CD23/FcεRII：分子的多任务处理。
CD23/FcεRII: molecular multi-tasking.
机构信息
Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, CR-UK Beatson Institute, Glasgow, UK.
出版信息
Clin Exp Immunol. 2010 Oct;162(1):12-23. doi: 10.1111/j.1365-2249.2010.04210.x.
Abstract
CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.
摘要
CD23 是免疫球蛋白 (Ig)E 的低亲和力受体，在 IgE 反应的调节中发挥重要作用。CD23 可以从细胞表面被切割，产生一系列具有多种细胞因子样活性的可溶性 CD23（sCD23）蛋白。负责与许多已知配体（包括 IgE、CD21、主要组织相容性复合体 (MHC) Ⅱ类和整合素）相互作用的 CD23 区域已被确定，有助于解释 CD23 蛋白的结构-功能关系。CD23 的转化研究强调了它作为治疗干预策略的靶标可信度，并说明了它在介导针对其他靶标的抗体的治疗效果中的作用。
相似文献
1
CD23/FcεRII: molecular multi-tasking.
Clin Exp Immunol. 2010 Oct;162(1):12-23. doi: 10.1111/j.1365-2249.2010.04210.x.
2
Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E.
J Biol Chem. 2013 Jul 26;288(30):21667-77. doi: 10.1074/jbc.M113.480657. Epub 2013 Jun 17.
3
Comparative binding of soluble fragments (derCD23, sCD23, and exCD23) of recombinant human CD23 to CD21 (SCR 1-2) and native IgE, and their effect on IgE regulation.
Cell Immunol. 2011;271(2):371-8. doi: 10.1016/j.cellimm.2011.08.003. Epub 2011 Aug 12.
4
Soluble CD21 (sCD21) forms biologically active complexes with CD23: sCD21 is present in normal plasma as a complex with trimeric CD23 and inhibits soluble CD23-induced IgE synthesis by B cells.
Int Immunol. 1998 Oct;10(10):1459-66. doi: 10.1093/intimm/10.10.1459.
5
The structure of human CD23 and its interactions with IgE and CD21.
J Exp Med. 2005 Sep 19;202(6):751-60. doi: 10.1084/jem.20050811.
6
alphavbeta5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein.
J Biol Chem. 2007 Sep 14;282(37):27315-27326. doi: 10.1074/jbc.M609335200. Epub 2007 May 31.
7
Structure and dynamics of IgE-receptor interactions: FcεRI and CD23/FcεRII.
Immunol Rev. 2015 Nov;268(1):222-35. doi: 10.1111/imr.12340.
8
CTLA4Fcε, a novel soluble fusion protein that binds B7 molecules and the IgE receptors, and reduces human in vitro soluble CD23 production and lymphocyte proliferation.
Immunology. 2016 May;148(1):40-55. doi: 10.1111/imm.12586. Epub 2016 Mar 8.
9
Structure-based modeling of the ligand binding domain of the human cell surface receptor CD23 and comparison of two independently derived molecular models.
Protein Sci. 1996 Feb;5(2):240-7. doi: 10.1002/pro.5560050207.
10
The importance of Lys-352 of human immunoglobulin E in FcepsilonRII/CD23 recognition.
J Biol Chem. 2004 Aug 20;279(34):35320-5. doi: 10.1074/jbc.M404575200. Epub 2004 Jun 15.
引用本文的文献
1
Decoding the immune microenvironment of secondary chronic myelomonocytic leukemia due to diffuse large B-cell lymphoma with CD19 CAR-T failure by single-cell RNA-sequencing.
Chin Med J (Engl). 2025 Aug 5;138(15):1866-1881. doi: 10.1097/CM9.0000000000003690. Epub 2025 Jul 7.
2
Effects of sample age and storage temperature on the flow cytometric diagnosis of chronic lymphocytic leukaemia in South Africa.
Afr J Lab Med. 2025 May 31;14(1):2688. doi: 10.4102/ajlm.v14i1.2688. eCollection 2025.
3
Structural and Functional Insights Into IgE Receptor Interactions and Disruptive Inhibition.
Immunol Rev. 2025 May;331(1):e70031. doi: 10.1111/imr.70031.
4
Vaccine-Induced Anti-IgE Antibodies Neutralize Free IgE but Fail to Bind and Activate Mast Cell-Displayed IgE.
Allergy. 2025 Jul;80(7):1995-2007. doi: 10.1111/all.16530. Epub 2025 Apr 7.
5
Effects of house-cultivated edible bird's nest on immunoglobulin and cytokine release .
Vet World. 2024 Jun;17(6):1370-1384. doi: 10.14202/vetworld.2024.1370-1384. Epub 2024 Jun 28.
6
A Comparison of Natural and Therapeutic Anti-IgE Antibodies.
Antibodies (Basel). 2024 Jul 16;13(3):58. doi: 10.3390/antib13030058.
7
CAR-NKT Cells in Asthma: Use of NKT as a Promising Cell for CAR Therapy.
Clin Rev Allergy Immunol. 2024 Jun;66(3):328-362. doi: 10.1007/s12016-024-08998-0. Epub 2024 Jul 12.
8
Heterogeneity of hepatocyte dynamics restores liver architecture after chemical, physical or viral damage.
Nat Commun. 2024 Feb 10;15(1):1247. doi: 10.1038/s41467-024-45439-0.
9
The Association between Vitamin D, Interleukin-4, and Interleukin-10 Levels and CD23+ Expression with Bronchial Asthma in Stunted Children.
Biomedicines. 2023 Sep 15;11(9):2542. doi: 10.3390/biomedicines11092542.
10
The development of blood protein profiles in extremely preterm infants follows a stereotypic evolution pattern.
Commun Med (Lond). 2023 Aug 2;3(1):107. doi: 10.1038/s43856-023-00338-1.
本文引用的文献
1
ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo.
J Exp Med. 2010 Mar 15;207(3):623-35. doi: 10.1084/jem.20091990. Epub 2010 Feb 15.
2
CD23 expression in plasma cell myeloma is specific for abnormalities of chromosome 11, and is associated with primary plasma cell leukaemia in this cytogenetic sub-group.
Br J Haematol. 2010 Apr;149(2):292-3. doi: 10.1111/j.1365-2141.2009.08042.x. Epub 2010 Jan 8.
3
Interaction of functional FCER2 promoter polymorphism and phenotype-associated haplotypes.
Tissue Antigens. 2009 Dec;74(6):534-8. doi: 10.1111/j.1399-0039.2009.01360.x. Epub 2009 Oct 21.
4
Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia.
Blood. 2010 Jan 21;115(3):489-95. doi: 10.1182/blood-2009-08-237727. Epub 2009 Oct 20.
5
CD23 mediates antimycobacterial activity of human macrophages.
Infect Immun. 2009 Dec;77(12):5537-42. doi: 10.1128/IAI.01457-08. Epub 2009 Oct 5.
6
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis.
Nat Rev Rheumatol. 2009 Oct;5(10):578-82. doi: 10.1038/nrrheum.2009.181.
7
Predictors of poor response during asthma therapy differ with definition of outcome.
Pharmacogenomics. 2009 Aug;10(8):1231-42. doi: 10.2217/pgs.09.86.
8
SDF-1 and PDGF enhance alphavbeta5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines.
Leukemia. 2009 Oct;23(10):1807-17. doi: 10.1038/leu.2009.126. Epub 2009 Jul 16.
9
Functional and clinical consequences of Fc receptor polymorphic and copy number variants.
Clin Exp Immunol. 2009 Aug;157(2):244-54. doi: 10.1111/j.1365-2249.2009.03980.x.
10
Molecular blocking of CD23 supports its role in the pathogenesis of arthritis.
PLoS One. 2009;4(3):e4834. doi: 10.1371/journal.pone.0004834. Epub 2009 Mar 12.
Zotero 插件