Division of Molecular and Cellular Biology, Faculty of Biomedical and Life Sciences, University of Glasgow, CR-UK Beatson Institute, Glasgow, UK.
Clin Exp Immunol. 2010 Oct;162(1):12-23. doi: 10.1111/j.1365-2249.2010.04210.x.
CD23 is the low-affinity receptor for immunoglobulin (Ig)E and plays important roles in the regulation of IgE responses. CD23 can be cleaved from cell surfaces to yield a range of soluble CD23 (sCD23) proteins that have pleiotropic cytokine-like activities. The regions of CD23 responsible for interaction with many of its known ligands, including IgE, CD21, major histocompatibility complex (MHC) class II and integrins, have been identified and help to explain the structure-function relationships within the CD23 protein. Translational studies of CD23 underline its credibility as a target for therapeutic intervention strategies and illustrate its involvement in mediating therapeutic effects of antibodies directed at other targets.
CD23 是免疫球蛋白 (Ig)E 的低亲和力受体，在 IgE 反应的调节中发挥重要作用。CD23 可以从细胞表面被切割，产生一系列具有多种细胞因子样活性的可溶性 CD23（sCD23）蛋白。负责与许多已知配体（包括 IgE、CD21、主要组织相容性复合体 (MHC) Ⅱ类和整合素）相互作用的 CD23 区域已被确定，有助于解释 CD23 蛋白的结构-功能关系。CD23 的转化研究强调了它作为治疗干预策略的靶标可信度，并说明了它在介导针对其他靶标的抗体的治疗效果中的作用。
