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家燕盏对免疫球蛋白及细胞因子释放的影响

Effects of house-cultivated edible bird's nest on immunoglobulin and cytokine release .

作者信息

Choong Mel June, Dewadas Hemaniswarri Dewi, Cheng Lim Lay, Sukuru Sheela Devi, Tan Chee Hong, Cheong Soon Keng, Lim Yang Mooi

机构信息

Centre for Cancer Research, M. Kandiah Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, 43000 Kajang, Selangor, Malaysia.

Centre for Biomedical and Nutrition Research, Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Kampar, 31900, Perak, Malaysia.

出版信息

Vet World. 2024 Jun;17(6):1370-1384. doi: 10.14202/vetworld.2024.1370-1384. Epub 2024 Jun 28.

DOI:10.14202/vetworld.2024.1370-1384
PMID:39077458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11283608/
Abstract

BACKGROUND AND AIM

Edible bird's nest (EBN) is known as the "Caviar of the East" because of its high nutritional and medicinal values. Nevertheless, its effect on human immunity is yet to be explored. This study examined the effects of EBN's aqueous extract (EBNE) on human immunity through the modular immune construct (MIMIC) model consisting of peripheral tissue equivalent (PTE) and lymphoid tissue equivalent (LTE) modules.

MATERIALS AND METHODS

One hundred twenty mL of full blood was obtained from four healthy human volunteers. The human immune system was simulated using an model, called MIMIC. Under EBNE treatment, monocyte transendothelial migration through reversed endothelial layers was observed. Using PTE and LTE modules, monocytes were differentiated into dendritic cells with lipopolysaccharide, then co-cultured with T- and B-cells for cytokine and immunoglobulin (Ig) production. The human cytokine array G2000 and quantitative human Ig isotyping array were used to identify the cytokine profile and Ig isotypes, respectively.

RESULTS

IgE, IgA, and IgG3 levels were significantly raised by EBNE. These cytokines, including brain-derived neurotrophic factor, ciliary neurotrophic factor, glial cell line-derivative neurotrophic factor, insulin-like growth factor 1, and insulin-like growth factor binding protein 4, were generated.

CONCLUSION

For the first time, this work uses a MIMIC model to illustrate the impact of EBNE on human immune response. This new understanding of EBN's immunoregulatory effect allows for further exploration of how EBN interacts with the human immune system.

摘要

背景与目的

由于其高营养价值和药用价值，食用燕窝（EBN）被誉为“东方鱼子酱”。然而，其对人体免疫力的影响尚待探索。本研究通过由外周组织等效物（PTE）和淋巴组织等效物（LTE）模块组成的模块化免疫构建体（MIMIC）模型，研究了EBN水提取物（EBNE）对人体免疫力的影响。

材料与方法

从四名健康人类志愿者身上采集了120毫升全血。使用一种名为MIMIC的模型模拟人体免疫系统。在EBNE处理下，观察单核细胞通过反向内皮细胞层的跨内皮迁移。使用PTE和LTE模块，将单核细胞用脂多糖分化为树突状细胞，然后与T细胞和B细胞共培养以产生细胞因子和免疫球蛋白（Ig）。分别使用人类细胞因子阵列G2000和定量人类Ig同型阵列来鉴定细胞因子谱和Ig同型。

结果

EBNE显著提高了IgE、IgA和IgG3水平。产生了这些细胞因子，包括脑源性神经营养因子、睫状神经营养因子、胶质细胞系衍生神经营养因子、胰岛素样生长因子1和胰岛素样生长因子结合蛋白4。

结论

这项工作首次使用MIMIC模型来说明EBNE对人体免疫反应的影响。对EBN免疫调节作用的这一新认识有助于进一步探索EBN与人体免疫系统的相互作用方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8785/11283608/eb2f0093984c/Vetworld-17-1370-g011.jpg
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