Department of Oral Surgery, People's Dental College, Kathmandu, Nepal.
Int J Oral Maxillofac Surg. 2010 Dec;39(12):1181-5. doi: 10.1016/j.ijom.2010.05.014. Epub 2010 Sep 15.
Radiation therapy for oral carcinoma is therapeutically useful in dose of at least 6000 cGy but causes mucositis that severely interferes with oral function. The literature indicates that honey appears to promote wound healing, so the authors investigated whether its anti-inflammatory properties might limit the severity of radiation-induced oral mucositis. A single-blinded, randomized, controlled clinical trial was carried out to compare the mucositis-limiting qualities of honey with lignocaine. A visual assessment scale permitted scoring of degrees of mucositis and statistical evaluation of the results was performed using the χ(2) test. Only 1 of 20 patients in the honey group developed intolerable oral mucositis compared with the lignocaine group, indicating that honey is strongly protective (RR=0.067) against the development of mucositis. The proportion of patients with intolerable oral mucositis was lower in the honey group and this was statistically significant (p=0.000). Honey applied topically to the oral mucosa of patients undergoing radiation therapy appears to provide a distinct benefit by limiting the severity of mucositis. Honey is readily available, affordable and well accepted by patients making it useful for improving the quality of life in irradiated patients.
口腔癌的放射治疗在至少 6000 cGy 的剂量下具有治疗作用，但会引起严重干扰口腔功能的黏膜炎。文献表明蜂蜜似乎具有促进伤口愈合的作用，因此作者研究了其抗炎特性是否可以限制放射性口腔黏膜炎的严重程度。进行了一项单盲、随机、对照临床试验，以比较蜂蜜与利多卡因对黏膜炎的限制作用。使用视觉评估量表对黏膜炎的严重程度进行评分，并使用 χ(2)检验对结果进行统计学评估。与利多卡因组相比，只有 20 名患者中的 1 名在蜂蜜组中出现无法忍受的口腔黏膜炎，表明蜂蜜对黏膜炎的发展具有很强的保护作用（RR=0.067）。蜂蜜组中无法忍受的口腔黏膜炎患者比例较低，这具有统计学意义（p=0.000）。蜂蜜局部应用于接受放射治疗的口腔黏膜似乎通过限制黏膜炎的严重程度提供了明显的益处。蜂蜜易于获得、价格合理且被患者接受，因此可用于提高放疗患者的生活质量。
