Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago, 2160 South First Ave., Maywood, IL 60153, USA.
Brain Behav Immun. 2011 Jan;25(1):25-39. doi: 10.1016/j.bbi.2010.08.009. Epub 2010 Sep 9.
In this Introduction to the Named Series "Epigenetics, Brain, Behavior, and Immunity" an overview of epigenetics is provided with a consideration of the nature of epigenetic regulation including DNA methylation, histone modification and chromatin re-modeling. Illustrative examples of recent scientific developments are highlighted to demonstrate the influence of epigenetics in areas of research relevant to those who investigate phenomena within the scientific discipline of psychoneuroimmunology. These examples are presented in order to provide a perspective on how epigenetic analysis will add insight into the molecular processes that connect the brain with behavior, neuroendocrine responsivity and immune outcome.
在这个名为“表观遗传学、大脑、行为和免疫”的专题介绍中,提供了一个关于表观遗传学的概述,考虑了表观遗传调控的性质,包括 DNA 甲基化、组蛋白修饰和染色质重塑。本文突出了最近科学发展的一些例证,以表明在与心理神经免疫学研究领域相关的研究领域中,表观遗传学的影响。这些例证的提出是为了提供一个视角,说明表观遗传分析将如何深入了解连接大脑、行为、神经内分泌反应和免疫结果的分子过程。