Department of Public Health, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Am J Obstet Gynecol. 2010 Dec;203(6):563.e1-7. doi: 10.1016/j.ajog.2010.07.017. Epub 2010 Sep 15.
The objective was to explore whether different levels of depressive symptoms in pregnant women and their serum folate status combined were associated with the gestational age and birthweight of their offspring.
Data were derived from pregnant women in Amsterdam who completed a questionnaire covering depressive symptoms (Center for Epidemiological Studies Depression Scale) and from whom blood samples were taken to determine serum folate status. Only live-born singletons were included (n = 4044) in the multivariate regression analysis.
When adjusted for potential confounders, only the association between major depressive symptoms and gestational age remained significant (-0.2 weeks; 95% confidence interval, -0.4 to -0.1). Women with depressive symptoms and low folate status (7.6%) experienced the shortest gestational age (38.6 weeks) and lowest birthweight (3270 g) (there was no significant interaction).
Depressive symptoms were associated with shorter gestational age and related lower birthweight. The study results underline the importance of folic acid intake specifically in women suffering from depressive symptoms.
本研究旨在探讨孕妇不同程度的抑郁症状及其血清叶酸水平与胎儿胎龄和出生体重的关系。
本研究的数据来源于阿姆斯特丹的孕妇，她们完成了一份包含抑郁症状的问卷（流行病学研究中心抑郁量表），并采集了血样以确定血清叶酸水平。只有活产单胎（n = 4044）被纳入多元回归分析。
调整了潜在混杂因素后，只有重度抑郁症状与胎龄之间的关联仍然显著（-0.2 周；95%置信区间，-0.4 至-0.1）。有抑郁症状和低叶酸状态（7.6%）的女性经历了最短的胎龄（38.6 周）和最低的出生体重（3270 克）（无显著交互作用）。
抑郁症状与胎龄较短和出生体重较低有关。研究结果强调了叶酸摄入对患有抑郁症状的女性的重要性。
