Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei 10055, Taiwan.
Occup Environ Med. 2011 Jan;68(1):64-8. doi: 10.1136/oem.2009.052704. Epub 2010 Sep 10.
To investigate changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation associated with changes in long-term exposure to ambient air pollutants.
We conducted secondary analyses of data on blood pressure and blood biochemistry markers from the Social Environment and Biomarkers of Aging Study in Taiwan and air pollution data from the Taiwan Environmental Protection Administration in 2000. Associations of 1-year averaged criteria air pollutants (particulate matter with aerodynamic diameters <10 μm (PM(10)) and <2.5 μm (PM(2.5)), ozone (O(3)), nitrogen dioxide (NO(2)), sulfur dioxide and carbon monoxide) with systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein cholesterol, fasting glucose, haemoglobin A1c (HbA1c), interleukin 6 (IL-6) and neutrophils were explored by applying generalised additive models.
After controlling for potential confounders, we observed that increased 1-year averaged particulate air pollutants (PM(10) and PM(2.5)) and NO(2) were associated with elevated blood pressure, total cholesterol, fasting glucose, HbA1c, IL-6 and neutrophils. Associations of increased 1-year averaged O(3) with elevated blood pressure, total cholesterol, fasting glucose, HbA1c and neutrophils were also observed. In particular, our two-pollutant models showed that PM(2.5) was more significantly associated with end-point variables than two gaseous pollutants, O(3) and NO(2).
Changes in blood pressure, blood lipids, blood sugar and haematological markers of inflammation are associated with long-term exposure to ambient air pollutants. This might provide a link between air pollution and atherosclerotic cardiovascular diseases.
研究与长期暴露于环境空气污染物相关的血压、血脂、血糖和血液炎症标志物的变化。
我们对来自台湾社会环境与衰老生物标志物研究中的血压和血液生化标志物数据以及 2000 年台湾环境保护署的空气污染数据进行了二次分析。应用广义加性模型探讨了 1 年平均浓度的空气污染物（空气动力学直径<10μm 的颗粒物（PM(10)）和<2.5μm 的颗粒物（PM(2.5)）、臭氧（O(3)）、二氧化氮（NO(2)）、二氧化硫和一氧化碳）与收缩压、舒张压、总胆固醇、甘油三酯、高密度脂蛋白胆固醇、空腹血糖、糖化血红蛋白（HbA1c）、白细胞介素 6（IL-6）和中性粒细胞之间的关联。
在控制了潜在的混杂因素后，我们观察到，1 年平均颗粒物空气污染物（PM(10)和 PM(2.5)）和 NO(2)的增加与血压升高、总胆固醇、空腹血糖、HbA1c、IL-6 和中性粒细胞升高有关。O(3)增加与血压升高、总胆固醇、空腹血糖、HbA1c 和中性粒细胞升高也有关。特别是，我们的双污染物模型表明，PM(2.5)与终点变量的相关性比两种气态污染物 O(3)和 NO(2)更为显著。
血压、血脂、血糖和血液炎症标志物的变化与长期暴露于环境空气污染物有关。这可能为空气污染与动脉粥样硬化性心血管疾病之间提供了联系。
