Center for Population Health and Aging, Duke University, Durham, North Carolina 27708-0408, USA.
Rejuvenation Res. 2012 Aug;15(4):374-80. doi: 10.1089/rej.2011.1290. Epub 2012 May 18.
In genome-wide association studies (GWAS) of human life span, none of the genetic variants has reached the level of genome-wide statistical significance. The roles of such variants in life span regulation remain unclear.
A biodemographic analyses was done of genetic regulation of life span using data on low-significance longevity alleles selected in the earlier GWAS of the original Framingham cohort.
Age-specific survival curves considered as functions of the number of longevity alleles exhibit regularities known in demography as "rectangularization" of survival curves. The presence of such pattern confirms observations from experimental studies that regulation of life span involves genes responsible for stress resistance.
Biodemographic analyses could provide important information about the properties of genes affecting phenotypic traits.
在人类寿命的全基因组关联研究（GWAS）中，没有一个遗传变异达到全基因组统计学意义的水平。这些变异在寿命调节中的作用仍不清楚。
利用早期弗莱明翰队列 GWAS 中选择的低显著性长寿等位基因的数据，对寿命的遗传调节进行了生物人口学分析。
作为长寿等位基因数量函数的特定年龄的生存曲线表现出人口统计学中称为“生存曲线矩形化”的规律。这种模式的存在证实了实验研究的观察结果，即寿命的调节涉及负责抵抗应激的基因。
生物人口学分析可以提供关于影响表型特征的基因特性的重要信息。
