Lee Jin-Ah, Lee Mee-Young, Seo Chang-Seob, Jung Da Young, Lee Nam-Hun, Kim Jung-Hun, Ha Hyekyung, Shin Hyeun Kyoo
Herbal Medicine Evidence Based Medicine Research Center, Korea Institute of Oriental Medicine, Daejeon, Republic of Korea.
Biosci Biotechnol Biochem. 2010;74(9):1814-8. doi: 10.1271/bbb.100177. Epub 2010 Sep 7.
Despite ongoing intensive asthma research, the incidence of asthma is increasing worldwide. We investigated in this study the effects of Amomum compactum on ovalbumin (OVA)-induced asthma in a mouse model, and studied the possible mechanism for its anti-asthmatic action. Our data show that an A. compactum treatment markedly decreased the number of infiltrating eosinophils and the hypersecretion of mucus when compared with the effects on mice treated with OVA alone. The A. compactum treatment dose-dependently decreased the levels of reactive oxygen species (ROS) and T helper (Th)2 cytokines, including interleukin (IL)-4 and IL-5, in the bronchoalveolar lavage fluid (BALF), and a high dose of A. compactum effectively reduced the level of total immunoglobulin (Ig)E in the serum. Taken together, these data indicate that the administration of A. compactum may have potential therapeutic value when used as an adjuvant for the immunomodulatory treatment of allergic asthma.
尽管哮喘研究一直在深入进行，但全球哮喘发病率仍在上升。在本研究中，我们调查了阳春砂对卵清蛋白（OVA）诱导的小鼠哮喘模型的影响，并研究了其抗哮喘作用的可能机制。我们的数据表明，与仅用OVA处理的小鼠相比，阳春砂处理显著减少了浸润嗜酸性粒细胞的数量和黏液的过度分泌。阳春砂处理剂量依赖性地降低了支气管肺泡灌洗液（BALF）中活性氧（ROS）和辅助性T细胞（Th）2细胞因子（包括白细胞介素（IL）-4和IL-5）的水平，高剂量的阳春砂有效降低了血清中总免疫球蛋白（Ig）E的水平。综上所述，这些数据表明，阳春砂作为过敏性哮喘免疫调节治疗的佐剂可能具有潜在的治疗价值。
