Jung Chan-Hee, Rhee Eun-Jung, Choi Ji-Hoon, Bae Ji-Cheol, Yoo Seung-Hyun, Kim Won-Jun, Park Cheol-Young, Mok Ji Oh, Kim Chul Hee, Lee Won-Young, Oh Ki-Won, Park Sung-Woo, Kim Sun-Woo
Division of Endocrinology and Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.
Korean Diabetes J. 2010 Aug;34(4):237-43. doi: 10.4093/kdj.2010.34.4.237. Epub 2010 Aug 31.
We investigated the relationships of adiponectin/leptin (A/L) ratio with cardiovascular risk factors, insulin resistance index, and metabolic syndrome (MS) in apparently healthy Korean male adults.
Sixty-eight male subjects were enrolled among the participants of an annual health check-up program (mean age, 55.1 years). Percent body fat (%) was measured using a bioelectric impedance analyzer. Serum leptin level was measured via radioimmunoassay, and adiponectin level was measured using an enzyme-linked immunosorbent assay. Homeostasis model assessment (HOMA)-insulin resistance (IR) index was calculated, and the presence of metabolic syndrome was assessed.
Adiponectin, leptin, and A/L ratio showed significant correlations with percent body fat, lipid profile, and HOMA-IR. Mean leptin and HOMA-IR levels were significantly higher, while A/L ratio was significantly lower in subjects with MS. With increasing number of MS components, the mean values of leptin and HOMA-IR increased and the A/L ratio decreased. In multiple regression analysis, HOMA-IR was significantly correlated with triglyceride, fasting glucose, and A/L ratio, while A/L ratio was significantly correlated with body mass index and HOMA-IR. HOMA-IR and A/L ratio were significant predictors for each other after adjustment for other factors.
A/L ratio correlated well with lipid profile, HOMA-IR, and the presence and number of MS components in Korean male subjects.
我们研究了脂联素/瘦素（A/L）比值与健康的韩国成年男性心血管危险因素、胰岛素抵抗指数及代谢综合征（MS）之间的关系。
在年度健康体检项目参与者中纳入68名男性受试者（平均年龄55.1岁）。使用生物电阻抗分析仪测量体脂百分比（%）。通过放射免疫分析法测量血清瘦素水平，使用酶联免疫吸附测定法测量脂联素水平。计算稳态模型评估（HOMA）-胰岛素抵抗（IR）指数，并评估代谢综合征的存在情况。
脂联素、瘦素及A/L比值与体脂百分比、血脂谱及HOMA-IR均显示出显著相关性。MS患者的平均瘦素水平和HOMA-IR显著更高，而A/L比值显著更低。随着MS组分数量的增加，瘦素和HOMA-IR的平均值升高，A/L比值降低。在多元回归分析中，HOMA-IR与甘油三酯、空腹血糖及A/L比值显著相关，而A/L比值与体重指数和HOMA-IR显著相关。在调整其他因素后，HOMA-IR和A/L比值互为显著预测因子。
在韩国男性受试者中，A/L比值与血脂谱、HOMA-IR以及MS组分的存在和数量密切相关。
